| Increased concentration of arachidonic acid in erythrocyte membranes in chronically lead-exposed men. | |
| | |
MedLine Citation:
|
PMID: 10653437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Animals intoxicated by lead present alterations in the fatty acid composition of red blood cells (RBC). Since this altered fatty acid composition of membranes may be a general reflection of lead toxicosis, we have examined 12 clinically healthy lead-exposed male subjects for fatty acid composition of RBC membranes along with blood lead, serum calcium, and serum iron concentrations. Twelve unexposed age-matched male subjects were used as controls. Significantly increased levels of arachidonic acid (AA) were found as compared to matching healthy controls in the RBC of the lead-exposed subjects. The increase of AA correlated in a dose-dependent manner with elevation in lead, and with serum iron, while a negative correlation was found between AA and serum calcium. The known ability of lead to substitute for calcium, which is essential in activating phospholipase A2 for AA release from membrane phospholipids, may be the main reason for increased AA in RBC membranes. |
| | |
Authors:
|
W Osterode; F Ulberth |
Related Documents
:
|
2116177 - Effect of eicosapentaenoic acid on triacylglycerol transport in caco-2 cells. 9743477 - Effect of palmitic and lauric acids on the phospholipid bilayer membrane conductivity. 3123837 - Lipid composition of bacillus megaterium spores and spore membranes. 6341607 - The lipid-containing bacteriophage pr4. effects of altered lipid composition on the vir... 6935647 - Wavelength regulation in rhodopsin: effects of dipoles and amino acid side chains. 3730017 - Influence of anisotes trisulcus and crepis rueppellii extracts on sites of bile formati... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of toxicology and environmental health. Part A Volume: 59 ISSN: 1528-7394 ISO Abbreviation: J. Toxicol. Environ. Health Part A Publication Date: 2000 Jan |
Date Detail:
|
Created Date: 2000-02-10 Completed Date: 2000-02-10 Revised Date: 2006-02-16 |
Medline Journal Info:
|
Nlm Unique ID: 100960995 Medline TA: J Toxicol Environ Health A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 87-95 Citation Subset: IM |
Affiliation:
|
Department of Clinical Occupational Medicine, Universitätsklinik für Innere Medizin IV, Klinische Abteilung für Arbeitsmedizin, Wien, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arachidonic Acid / metabolism* Calcium / blood Erythrocyte Membrane / metabolism* Fatty Acids / metabolism Humans Iron / blood Lead / blood Lead Poisoning / blood* Male Occupational Diseases / blood* Occupational Exposure* |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 506-32-1/Arachidonic Acid; 7439-89-6/Iron; 7439-92-1/Lead; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Suppression of rat and mouse lymphocyte function by urban air particulates (Ottawa dust) is reversed...
Next Document: Neurotoxicity of ethyl methacrylate in rats.