Document Detail

Increased collagen prolyl hydroxylase activity in the aortic wall of rabbits exposed to chronic hypoxia.
MedLine Citation:
PMID:  228678     Owner:  NLM     Status:  MEDLINE    
The activity of collagen prolyl hydroxylase in aortic wall was studied in rabbits exposed to chronic 10% ambient oxygen tension for 30 days. Prolyl hydroxylase in rabbit aorta was shown to be similar to the enzyme from other sources in that it required molecular oxygen, alpha-ketoglutarate, ferrous iron and ascorbate for its activity. The activity of prolyl hydroxylase was increased to 180% of controls in the intima-media samples from rabbits exposed to hypoxia. No atherosclerotic lesions could be seen in arteries of animals kept in chronic hypoxia. If the arteries of rabbits were injured with a single mechanical dilatation, the activity of prolyl hydroxylase increased more than 2-fold, as reported previously. The exposure of these animals to chronic hypoxia further elevated the prolyl hydroxylase activity.
H Turto; S Lindy; J Uitto; P Helin; C Garbarsch; I B Lorenzen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  33     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1980-01-28     Completed Date:  1980-01-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
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MeSH Terms
Anoxia / enzymology*
Aorta / enzymology*,  metabolism
Arteriosclerosis / enzymology
Collagen / metabolism*
Procollagen-Proline Dioxygenase / analysis*
Reg. No./Substance:
9007-34-5/Collagen; EC Dioxygenase

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