Document Detail

Increased circulating levels of soluble HLA class I heterodimers in patients with sickle cell disease.
MedLine Citation:
PMID:  9549979     Owner:  NLM     Status:  MEDLINE    
This study examined the presence of a persistent state of low-grade inflammation in sickle cell anemia patients by measuring circulating sHLA-I heterodimers and C-reactive protein during the steady state and after recent crises. Thirty-nine pediatric sickle hemoglobinopathy patients were studied during the steady state and 11 patients were evaluated within 1 month of a painful crisis. A disease severity score was generated for each patient, and soluble HLA-I (sHLA-I) and C-reactive protein levels were determined. Soluble HLA-I was significantly elevated in 55% of the steady-state group and in 36% of the recent-crisis group. The percentage of patients with elevated sHLA-I differed in the various disease subgroups in the steady state: 46% of Hb SS patients, 70% of Hb SC patients, 75% of Hb S beta-thal patients, and 20% of Hb SSF patients. Steady-state and recent-crisis sHLA-I levels were not significantly different. C-reactive protein levels were elevated in 11% of steady-state patients and in 9% of recent-crisis patients. Soluble HLA-I levels did not correlate with C-reactive protein levels or disease severity score, age, hemoglobin, reticulocyte count, platelet count, or white cell count. These results show that the majority of sickle hemoglobinopathy patients have elevated sHLA-I levels during the steady state and after recent crisis, suggesting the presence of chronic inflammation during the steady state.
C Moore; M Ehlayel; J Inostroza; L E Leiva; S Kuvibidila; L Yu; R Gardner; D L Ode; R Warrier; R U Sorensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  90     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-08     Completed Date:  1998-05-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  IM    
Department of Pediatrics, Louisiana State University Medical Center, New Orleans 70112-2822, USA.
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MeSH Terms
Anemia, Sickle Cell / blood*,  immunology
C-Reactive Protein / analysis
Histocompatibility Antigens Class I / blood*
Severity of Illness Index
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 9007-41-4/C-Reactive Protein

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