| Increased circulating endothelins are not of cardiopulmonary origin in heart failure patients. | |
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MedLine Citation:
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PMID: 16076689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Plasma concentrations of endothelin-1 and big-endothelin are increased in heart failure patients. However, the precise contribution of endothelin secretion from the cardiopulmonary system remains unresolved. The aim of this study was to investigate whether the cardiopulmonary system contributes to the circulating endothelin-1 and big-endothelin concentrations in heart failure patients. MATERIAL AND METHODS: Blood samples were obtained at right heart catheterization from different cardiovascular regions including the coronary sinus in chronic heart failure patients (n=12) and from age-matched control subjects (n=12). RESULTS: The peripheral plasma concentrations of endothelin-1 were almost 3-fold higher in heart failure patients compared with the control subjects (1.25 pmol/l, 0.30-8.20 pmol/l (median, range) versus 0.46 pmol/l, 0.10-0.88 pmol/l, p<0.01). However, the endothelin-1 concentration was approximately 25% lower in plasma samples from the coronary sinus than in plasma from the inferior caval vein (p<0.05) in the heart failure patients. There were no differences in big-endothelin concentrations between any of the cardiovascular regions. CONCLUSIONS: In heart failure patients, increased plasma concentrations of endothelin-1 and big-endothelin mainly reflect an increased secretion from the peripheral endothelium. |
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Authors:
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Y Z Wang; J P Goetze; R Videbaek; J F Rehfeld; J Kastrup |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 65 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-08-03 Completed Date: 2005-10-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: Norway |
Other Details:
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Languages: eng Pagination: 341-7 Citation Subset: IM |
Affiliation:
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Medical Department B, Cardiac Catheterization Laboratory, the Heart Centre, and Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Denmark. wang@rh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiomyopathy, Dilated / blood Coronary Vessels / metabolism*, secretion Endothelin-1 / blood*, secretion Endothelium, Vascular / metabolism*, secretion Female Heart Catheterization Heart Failure / blood* Humans Male Middle Aged Vena Cava, Inferior / metabolism*, secretion Ventricular Dysfunction, Left / blood |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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