Document Detail

Increased circulating endothelins are not of cardiopulmonary origin in heart failure patients.
MedLine Citation:
PMID:  16076689     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Plasma concentrations of endothelin-1 and big-endothelin are increased in heart failure patients. However, the precise contribution of endothelin secretion from the cardiopulmonary system remains unresolved. The aim of this study was to investigate whether the cardiopulmonary system contributes to the circulating endothelin-1 and big-endothelin concentrations in heart failure patients. MATERIAL AND METHODS: Blood samples were obtained at right heart catheterization from different cardiovascular regions including the coronary sinus in chronic heart failure patients (n=12) and from age-matched control subjects (n=12). RESULTS: The peripheral plasma concentrations of endothelin-1 were almost 3-fold higher in heart failure patients compared with the control subjects (1.25 pmol/l, 0.30-8.20 pmol/l (median, range) versus 0.46 pmol/l, 0.10-0.88 pmol/l, p<0.01). However, the endothelin-1 concentration was approximately 25% lower in plasma samples from the coronary sinus than in plasma from the inferior caval vein (p<0.05) in the heart failure patients. There were no differences in big-endothelin concentrations between any of the cardiovascular regions. CONCLUSIONS: In heart failure patients, increased plasma concentrations of endothelin-1 and big-endothelin mainly reflect an increased secretion from the peripheral endothelium.
Y Z Wang; J P Goetze; R Videbaek; J F Rehfeld; J Kastrup
Related Documents :
6492059 - Myocardial pathology of domestic ruminants in southern africa.
11111149 - Isolated left ventricular abnormal trabeculation is a cardiac manifestation of neuromus...
23811839 - Integrating the knowledge: strength and limitations of echo techniques to diagnose and ...
11832669 - Difficult cases in heart failure. novel diagnostic markers in heart failure: an emergin...
16084759 - The modification of diet in renal disease (mdrd) equations provide valid estimations of...
3831029 - Improvement by denopamine (ta-064) of pentobarbital-induced cardiac failure in the dog ...
10149209 - Percutaneous coronary angioscopy: methods, findings, and therapeutic implications.
2924609 - Treatment of congestive heart failure. its effect on pleural fluid chemistry.
14636759 - Roles of ischemia and hypoxia and the molecular pathogenesis of post-burn cardiac shock.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  65     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-03     Completed Date:  2005-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
Medical Department B, Cardiac Catheterization Laboratory, the Heart Centre, and Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiomyopathy, Dilated / blood
Coronary Vessels / metabolism*,  secretion
Endothelin-1 / blood*,  secretion
Endothelium, Vascular / metabolism*,  secretion
Heart Catheterization
Heart Failure / blood*
Middle Aged
Vena Cava, Inferior / metabolism*,  secretion
Ventricular Dysfunction, Left / blood
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Deformability of passive and activated neutrophils in children with Gram-negative septicemia.
Next Document:  Targeted drugs in metastatic colorectal cancer with special emphasis on guidelines for the use of be...