Document Detail


Increased chemiluminescence of whole blood and normal T-lymphocyte subsets in severe nodular acne and acne fulminans.
MedLine Citation:
PMID:  7747527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the inflammatory and immunological aspects of severe acne, we examined the luminol-enhanced chemiluminescence of whole blood, T-cell subsets and natural killer cell functions in 11 patients with severe nodular acne and 4 patients with acne fulminans. In patients with severe nodular acne, the active phase of the disease, compared to the values in remission (means 47 mV, SD 24.8 and 32 mV, SD 8.3, p < 0.05). The patients with acne fulminans also showed high values in the active phase of the disease (mean mV 68.3, SD3.5) compared to remission (mean 30.5 mV, SD 15.3). No marked alterations were seen in the percentages of T-helper cells, T-suppressor cells or DR-positive lymphocytes or in the levels of soluble interleukin 2 receptor. The percentages and activities of natural killer cells did not show any significant changes either. Five patients (4 with severe nodular acne and one with acne fulminans, accounting for 33% of all patients) carried HLA Cw6 antigen, which is a significantly increased frequency compared to health controls (pc = 0.015). The present chemiluminescence results suggest that peripheral blood neutrophils are activated in patients with severe acne.
Authors:
S L Karvonen; L Räsänen; E Soppi; H Hyöty; M Lehtinen; T Reunala
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  75     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-09     Completed Date:  1995-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM; X    
Affiliation:
Department of Dermatology, University Hospital of Oulu, Finland.
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / blood*,  drug therapy,  immunology
Adolescent
Adult
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Chemiluminescent Measurements
Female
HLA-C Antigens / analysis
HLA-DR Antigens / analysis
Humans
Killer Cells, Natural / immunology
Luminol / diagnostic use
Male
Neutrophils / immunology
Receptors, IgG / analysis
Receptors, Interleukin-2 / analysis
Remission Induction
T-Lymphocyte Subsets / immunology*
T-Lymphocytes, Helper-Inducer / immunology
T-Lymphocytes, Regulatory / immunology
Chemical
Reg. No./Substance:
0/HLA-C Antigens; 0/HLA-Cw6; 0/HLA-DR Antigens; 0/Receptors, IgG; 0/Receptors, Interleukin-2; 521-31-3/Luminol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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