| Increased cerebral blood flow velocities assessed by transcranial doppler examination is associated with complement activation after cardiopulmonary bypass. | |
| | |
MedLine Citation:
|
PMID: 21173036 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The role of complement activation on the cerebral vasculature after cardiopulmonary bypass (CPB) is unclear. The goal of the study was to assess whether heparin-coated CPB reduces complement activation, and influences cerebral blood flow velocities (CBFV). Twenty-four patients undergoing coronary surgery were randomly allocated to non-coated (NC-group) or heparin-coated (HC-group) CPB. Complement activation was assessed by measuring sC5b-9. Transcranial Doppler (TCD) was performed on middle cerebral arteries before and after CPB. Systolic (SV), diastolic (DV) and mean (MV) CBFV were measured. Significant increase of sC5b-9 (p=0.003) was observed in the NC-group and CBFV increased after CPB (SV by 27%, p=0.05; DV by 40%, p=0.06; MV by 33%, p=0.04) whereas no changes were detected in the HC-group. TCD values were higher in the NC-group than in the HC-group (SV, p=0.04; DV, p=0.03; MV, p=0.03) although cardiac index, systemic vascular resistance, haematocrit and pCO(2) were similar. Postoperative SV, DV and MV were significantly correlated with sC5b-9 (r=0.583, p=0.009; r=0.581, p=0.009; r=0.598, p=0.007, respectively). Increased CBFV after CPB are correlated to the level of complement activation and may be controlled by heparin-coated circuits. |
| | |
Authors:
|
C Baufreton; F Pinaud; J-J Corbeau; A Chevailler; D Jolivot; A Ter Minassian; D Henrion; J-L De Brux |
Related Documents
:
|
6136946 - The microcirculation. 879306 - Perfusion rates and the transfer of water across isolated guinea pig placenta. 13549646 - Host-homograft tissue interactions following exchange blood transfusions in rabbits. 986646 - Exchange transfusion with plasmapheresis in the management of hepatic coma. 7081126 - The relationship between high fibrinolytic activity and daily capsicum ingestion in thais. 3921366 - Polychlorinated biphenyls, dibenzofurans and quaterphenyls in toxic rice-bran oil and i... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-20 |
Journal Detail:
|
Title: Perfusion Volume: - ISSN: 1477-111X ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8700166 Medline TA: Perfusion Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Cardiac Surgery, University Hospital, Angers, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Using cerebral oximetry to prevent adverse outcomes during cardiac surgery.
Next Document: Aortic arch replacement with moderate hypothermia and a modified 3 pumpcircuit.