Document Detail

Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study.
MedLine Citation:
PMID:  14698999     Owner:  NLM     Status:  MEDLINE    
Impaired glucose metabolism (IGM) and type 2 diabetes (DM-2) are associated with high cardiovascular disease risk. Increases in peripheral and central artery stiffness may represent pathophysiologic pathways through which glucose tolerance status leads to cardiovascular disease. Peripheral artery stiffness increases with deteriorating glucose tolerance status, whereas this trend remains unclear for central artery stiffness. Therefore, we investigated the associations between glucose tolerance status and estimates of central arterial stiffness. We performed a population-based study of 619 individuals (normal glucose metabolism, n=261; IGM, n=170; and DM-2, n=188) and assessed central artery stiffness by measuring total systemic arterial compliance, aortic pressure augmentation index, and carotid-femoral transit time. After adjustment for sex, age, heart rate, height, body mass index, and mean arterial pressure, DM-2 was associated with decreased total systemic arterial compliance, increased aortic augmentation index, and decreased carotid-femoral transit time. IGM was borderline significantly associated with decreased total systemic arterial compliance. Respective regression coefficients (95% confidence intervals) for IGM and DM-2 compared with normal glucose metabolism were -0.05 (-0.11 to 0.01) and -0.13 (-0.19 to -0.07) mL/mm Hg for total systemic arterial compliance; 1.1 (-0.2 to 2.5) and 1.6 (0.2 to 3.0) percentage points for aortic augmentation index; and -0.85 (-5.20 to 3.49) and -4.95 (-9.41 to -0.48) ms for carotid-femoral transit time. IGM and DM-2 are associated with increased central artery stiffness, which is more pronounced in DM-2. Deteriorating glucose tolerance is associated with increased central and peripheral arterial stiffness, which may partly explain why both DM-2 and IGM are associated with increased cardiovascular risk.
Miranda T Schram; Ronald M A Henry; Rob A J M van Dijk; Piet J Kostense; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Nico Westerhof; Coen D A Stehouwer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-12-29
Journal Detail:
Title:  Hypertension     Volume:  43     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-30     Completed Date:  2004-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-81     Citation Subset:  IM    
Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Aorta / physiopathology
Arteries / physiopathology*
Blood Flow Velocity
Blood Pressure
Cardiovascular Diseases / etiology
Diabetes Mellitus, Type 2 / complications,  diagnosis,  physiopathology*
Glucose Metabolism Disorders / complications,  diagnosis,  physiopathology*
Glucose Tolerance Test
Pulsatile Flow
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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