| Increased cellular responsiveness to epinephrine in primary open-angle glaucoma. | |
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MedLine Citation:
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PMID: 193479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concentration of I-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P less than .05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels. |
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Authors:
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P F Palmberg; S Hajek; D Cooper; B Becker |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of ophthalmology Volume: 95 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-06-30 Completed Date: 1977-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 855-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Cyclic AMP / metabolism Epinephrine / pharmacology* Glaucoma* / metabolism Humans Lymphocyte Activation / drug effects* Middle Aged |
| Chemical | |
Reg. No./Substance:
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51-43-4/Epinephrine; 60-92-4/Cyclic AMP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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