Document Detail


Increased cellular responsiveness to epinephrine in primary open-angle glaucoma.
MedLine Citation:
PMID:  193479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of I-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P less than .05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.
Authors:
P F Palmberg; S Hajek; D Cooper; B Becker
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  95     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  855-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Cyclic AMP / metabolism
Epinephrine / pharmacology*
Glaucoma* / metabolism
Humans
Lymphocyte Activation / drug effects*
Middle Aged
Chemical
Reg. No./Substance:
51-43-4/Epinephrine; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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