| Increased carotid arterial stiffness in subclinical hypothyroidism. | |
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MedLine Citation:
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PMID: 21111945 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Arterial stiffness is involved in the pathophysiology of cardiovascular disease, and subclinical hypothyroidism (SCH) is associated with increased risk of atherosclerosis. The present study was designed to examine whether SCH is associated with an increase in carotid arterial stiffness. METHODS: The carotid arterial stiffness parameter in 93 patients with SCH and 90 sex- and age-matched euthyroid volunteers was evaluated using a color Doppler ultrasound machine implemented with a high-resolution echo-tracking system. RESULTS: The participants with SCH had higher total cholesterol, LDL-cholesterol and highly sensitive C-reactive protein (hsCRP) levels than those who were euthyroid. Furthermore, carotid arterial stiffness β (β index) was significantly higher in SCH patients than in normal controls, and β index was significantly positively correlated with age, smoking index, diastolic blood pressure, systolic blood pressure, TSH and hsCRP and significantly negatively correlated with pulse rate in subclinical hypothyroid patients. CONCLUSIONS: Subclinical hypothyroidism is associated with preclinical vascular alteration, characterized by increased carotid arterial stiffness values, which have been shown to be related to the hsCRP and TSH. |
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Authors:
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Limin Tian; Cuixia Gao; Jing Liu; Xuelan Zhang |
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Publication Detail:
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Type: Journal Article Date: 2010-09-15 |
Journal Detail:
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Title: European journal of internal medicine Volume: 21 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 560-3 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Endocrinology and Metabolism, People's Hospital of Gansu Province, 160 Dong Gang West Road, Lanzhou, 730000, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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