Document Detail

Increased cardiac output and lowered peripheral resistance during metoprolol treatment.
MedLine Citation:
PMID:  6579824     Owner:  NLM     Status:  MEDLINE    
Echocardiography was performed at every six months in hypertensives well controlled on metoprolol, 100 mg twice a day. After six months' treatment blood pressure was reduced from 177/110 mm Hg to 147/88 (p less than 0.02). LV wall thickness (septum + posterior wall) was unchanged 2.10 cm (2.14), and a significant drop in cardiac output (CO) to 5.0 l/min (6.1, p less than 0.02) was recorded (pretreatment values in brackets). After 24 months' treatment LV wall thickness was reduced to 1.94 cm (p less than 0.02), total peripheral resistance (TPR) to 17.3 mm Hg/l/min (23.4, p less than 0.02) and CO increased to 6.7 l/min (6.1, n.s.). After six months' treatment, there was thus a drop in BP with a significant drop in CO and unchanged TPR. After 24 months' treatment, however, CO was back to the pretreatment level and the drop in BP was entirely caused by a drop in TPR which was probably secondary to a reduction in the wall thickness of the arterial resistance vessels as judged by the relationship between the reduction in wall thickness in the LV and the reduction in TPR during the treatment.
J Wikstrand; B Trimarco; G Buzzetti; B Ricciardelli; N de Luca; M Volpe; M Condorelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica. Supplementum     Volume:  672     ISSN:  0365-463X     ISO Abbreviation:  Acta Med. Scand. Suppl.     Publication Date:  1983  
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370331     Medline TA:  Acta Med Scand Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Capillary Resistance / drug effects*
Cardiac Output / drug effects*
Heart Ventricles / pathology
Hypertension / drug therapy*,  pathology,  physiopathology
Metoprolol / therapeutic use*
Middle Aged
Reg. No./Substance:

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