Document Detail


Increased carbon monoxide clearance during exercise in humans.
MedLine Citation:
PMID:  22648340     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Hyperventilation increases the clearance of carbon monoxide (CO) from blood, thus we hypothesised that CO elimination would be enhanced with exercise. Accordingly, this study examined the effect of exercise on the half-life of carboxyhemolobin elimination. METHODS: Six healthy subjects (3 males and 3 females) with mean (SD) ages of 23 (4) years were exposed to CO sufficient to raise blood carboxyhemolobin concentration to 10 to 14% on 5 separate days. The half-life for CO elimination was measured breathing room air at rest and during exercise at three intensities. RESULTS: Comparisons showed that the half-life decreased with exercise from that during rest in all subjects. The half-life was also measured during 100% oxygen breathing at the lowest exercise intensity of 63 (15) W and found to be the least of all measured [(23 (4) min]. CONCLUSIONS: (1) exercise increased isocapnic ventilation thereby decreasing the half-life of CO elimination. (2) The half-life of CO elimination represents a hyperbolic function of ventilation [y= y0 + (a/x)] and so increasing ventilation by exercise reaches a point of diminishing returns. (3) Breathing 100% oxygen during mild exercise is as effective in eliminating CO as treatment with hyperbaric oxygen. (4) Moderate exercise under room air conditions is as effective in eliminating CO as breathing oxygen at rest. Thus, the combination of mild exercise, hyperventilation, and normobaric hyperoxia (100% oxygen inhalation), may be considered the "triple therapy" for CO elimination in some patients.
Authors:
Gerald S Zavorsky; James M Smoliga; Lawrence D Longo; Kathy A Uhranowsky; Christopher R Cadman; James Duffin; Joseph A Fisher
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-29
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Human Physiology Laboratory, Marywood University, Scranton, PA 2The Commonwealth Medical College, Scranton, PA 3Department of Physical Therapy, High Point University, High Point, NC 4Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, California, USA, 92350 5Princeton University, Princeton, NJ 6Department of Physiology, University of Toronto, Toronto, Canada 7Department of Anesthesia, University Health Network, University of Toronto, Toronto, Canada.
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