Document Detail

Increased capacity for fatty acid synthesis in white and brown adipose tissues from 7-day-old obese Zucker pups.
MedLine Citation:
PMID:  3905649     Owner:  NLM     Status:  MEDLINE    
The activity of fatty acid synthetase was measured in liver, and white and brown adipose tissues of suckling lean and obese Zucker pups. In contrast to liver where no change could be observed, a significant increase in fatty acid synthetase activity was detected in both white and brown adipose tissues as early as 7 days of age. When the enzyme activity was expressed per inguinal fat pad whose weight was increased by 30 per cent in obese as compared to lean pups, a 50 per cent increase in fatty acid synthetase activity was observed. The increased activity was mediated through an increased enzyme content. Insulin levels were still identical in the two groups at 16 days of age but were significantly increased at days 17 and 18 in obese as compared to lean pups. The aetiological role of the increase in fatty acid synthetase, which is expressed in vivo, is discussed.
M Lavau; R Bazin; M Guerre-Millo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of obesity     Volume:  9 Suppl 1     ISSN:  -     ISO Abbreviation:  Int J Obes     Publication Date:  1985  
Date Detail:
Created Date:  1986-01-21     Completed Date:  1986-01-21     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7703240     Medline TA:  Int J Obes     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / enzymology*
Adipose Tissue, Brown / enzymology*
Animals, Suckling
Body Weight
Fatty Acid Synthases / metabolism
Fatty Acids / biosynthesis*
Hyperinsulinism / enzymology
Insulin / blood
Liver / enzymology
Obesity / enzymology*
Rats, Zucker
Reg. No./Substance:
0/Fatty Acids; 0/Insulin; EC Acid Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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