Document Detail


Increased capacity of the coronary arteries in chronic Chagas' heart disease: further support for the neurogenic pathogenesis concept.
MedLine Citation:
PMID:  3155586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A postmortem study of the capacity of the coronary arteries is presented. The amount of injected Schlessinger's barium-gelatin mass taken up by the coronary arterial tree under standard conditions was used as a measure of coronary capacity. A total of 63 hearts, consisting of those with Chagas' cardiopathy, normal hearts, and hypertrophied hearts, were studied. Correlation coefficients between coronary capacity and heart weight, as well as index of coronary capacity based on heart weight, were the parameters submitted to statistical analysis. Positive correlation coefficients between coronary capacity and heart weight were detected in normal and chagasic cases but not in hypertrophied cases. Multiple comparisons of the indexes showed a highly significant increase of coronary capacity in chagasic cases when compared with normal (p less than 0.005) and hypertrophied hearts (p less than 0.01). The characteristic parasympathetic denervation, resulting in a relative sympathetic overdrive, is suggested to be the basic cause of enlargement of the coronary tree in Chagas' heart disease, thus providing further support for the neurogenic pathogenetic concept.
Authors:
J S Oliveira; J C dos Santos; G Muccillo; A L Ferreira
Related Documents :
19429856 - Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate...
10213346 - Prevalence of left ventricular hypertrophy in a general population; the tromsø study.
2944766 - Physiological adaptation of the heart to pathological overloading.
19836216 - Vitamin d deficiency in the spontaneously hypertensive heart failure [shhf] prone rat.
22009446 - Resolving inequalities in care? reduced mortality in the elderly after acute coronary s...
1279626 - Relationship between spectral measures of heart rate variability and ventricular ectopi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  109     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-02-21     Completed Date:  1985-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Cardiomegaly / physiopathology
Chagas Cardiomyopathy / physiopathology*
Coronary Vessels / physiopathology
Female
Humans
Male
Organ Size
Parasympathetic Nervous System / physiopathology
Sympathetic Nervous System / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparative hemodynamic effects of intravenous dobutamine and MDL-17,043, a new cardioactive drug, i...
Next Document:  Electrocardiographic diagnosis of left ventricular hypertrophy in the presence of left bundle branch...