Document Detail


Increased calcium deposits and decreased Ca2+-ATPase in right ventricular myocardium of ascitic broiler chickens.
MedLine Citation:
PMID:  17054481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Right ventricular hypertrophy and failure is an important step in the development of ascites syndrome (AS) in broiler chickens. Cytoplasmic calcium concentration is a major regulator of cardiac contractile function and various physiological processes in cardiac muscle cells. The purpose of this study was to measure the right ventricular pressure and investigate the precise ultrastructural location of Ca(2+) and Ca(2+)-ATPase in the right ventricular myocardium of chickens with AS induced by low ambient temperature. The results showed that the right ventricular diastolic pressure of ascitic broilers was significantly higher than that of control broilers (P < 0.01), and the maximum change ratio of right intraventricular pressure (RV +/- dp/dt(max)) of ascitic broilers was significantly lower than that of the controls (P < 0.01). Extensively increased calcium deposits were observed in the right ventricular myocardium of ascitic broilers, whereas in the age-matched control broilers, calcium deposits were much less. The Ca(2+)-ATPase reactive products were obviously found on the sarcoplasmic reticulum and mitochondrial membrane of the control right ventricular myocardium, but rarely observed in the ascitic broilers. The data suggest that in ascitic broilers there is the right ventricular diastolic dysfunction, in which the overload of intracellular calcium and the decreased Ca(2+)-ATPase activity might be the important factors.
Authors:
K Li; J Qiao; L Zhao; S Dong; D Ou; J Wang; H Wang; T Xu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine     Volume:  53     ISSN:  0931-184X     ISO Abbreviation:  J Vet Med A Physiol Pathol Clin Med     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100955112     Medline TA:  J Vet Med A Physiol Pathol Clin Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  458-63     Citation Subset:  IM    
Affiliation:
Department of Animal Physiopathology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ascites / metabolism,  pathology,  veterinary*
Calcium / metabolism*
Calcium-Transporting ATPases / metabolism,  ultrastructure
Chickens*
Heart Ventricles / metabolism,  pathology,  ultrastructure
Hypertrophy, Right Ventricular / metabolism,  pathology,  veterinary*
Male
Microscopy, Electron, Transmission / veterinary
Myocardium / metabolism*,  pathology,  ultrastructure
Poultry Diseases / metabolism,  pathology*
Chemical
Reg. No./Substance:
7440-70-2/Calcium; EC 3.6.1.8/Calcium-Transporting ATPases

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