| Increased bone resorption and impaired bone microarchitecture in short-term and extended high-fat diet-induced obesity. | |
| | |
MedLine Citation:
|
PMID: 20171704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although obesity traditionally has been considered a condition of low risk for osteoporosis, this classic view has recently been questioned. The aim of this study was to assess bone microarchitecture and turnover in a mouse model of high-fat diet-induced obesity. Seven-week-old male C57BL/6J mice (n = 18) were randomized into 3 diet groups. One third (n = 6) received a low-fat diet for 24 weeks, one third was kept on an extended high-fat diet (eHF), and the remaining was switched from low-fat to high-fat chow 3 weeks before sacrifice (sHF). Serum levels of insulin, leptin, adiponectin, osteocalcin, and cross-linked telopeptides of type I collagen (CTX) were measured. In addition, bone microarchitecture was analyzed by micro-computed tomography; and lumbar spine bone density was assessed by dual-energy x-ray absorptiometry. The CTX, body weight, insulin, and leptin were significantly elevated in obese animals (sHF: +48%, +24%, +265%, and +102%; eHF: +43%, +52%, +761%, and +292%). The CTX, body weight, insulin, and leptin showed a negative correlation with bone density and bone volume. Interestingly, short-term high-fat chow caused similar bone loss as extended high-fat feeding. Bone volume was decreased by 12% in sHF and 19% in eHF. Bone mineral density was 25% (sHF) and 27% (eHF) lower when compared with control mice on low-fat diet. As assessed by the structure model index, bone microarchitecture changed from plate- to rod-like appearance upon high-fat challenge. Trabecular and cortical thickness remained unaffected. Short-term and extended high-fat diet-induced obesity caused significant bone loss in male C57BL/6J mice mainly because of resorptive changes in trabecular architecture. |
| | |
Authors:
|
Janina M Patsch; Florian W Kiefer; Peter Varga; Pamela Pail; Martina Rauner; Daniela Stupphann; Heinrich Resch; Doris Moser; Philippe K Zysset; Thomas M Stulnig; Peter Pietschmann |
Related Documents
:
|
20452104 - Different thermic effects of leptin in adolescent females with varying body fat content. 7100244 - Effect of chronic administration of dl-amphetamine and fenfluramine on adrenocortical f... 9950914 - Effect of diet on the response to leptin in the marsupial sminthopsis crassicaudata. 10629434 - Endocrine responses after d-fenfluramine and ipsapirone challenge: further support for ... 7601774 - Reducing particle size of corn in lactation diets from 1,200 to 400 micrometers improve... 12479944 - Diet influences cocaine withdrawal behaviors in the forced swimming test. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-20 |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: 60 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-24 Completed Date: 2011-03-04 Revised Date: 2011-04-06 |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
|
Languages: eng Pagination: 243-9 Citation Subset: IM |
Copyright Information:
|
© 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Cellular and Molecular Pathophysiology, Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University Vienna, A-1090 Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorptiometry, Photon Adiponectin / blood Adipose Tissue / metabolism Animals Bone Density / drug effects* Bone Resorption / metabolism*, radiography Bone and Bones / metabolism, radiography, ultrastructure* Collagen Type I / analysis Diet, Fat-Restricted Dietary Fats / administration & dosage* Insulin / blood Leptin / blood Lumbar Vertebrae / metabolism, radiography, ultrastructure Male Mice Mice, Inbred C57BL Obesity / etiology* Osteocalcin / blood |
| Grant Support | |
ID/Acronym/Agency:
|
P 20239-B13//Austrian Science Fund FWF |
| Chemical | |
Reg. No./Substance:
|
0/Adiponectin; 0/Collagen Type I; 0/Dietary Fats; 0/Leptin; 104982-03-8/Osteocalcin; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Simple virilizing forms of congenital adrenal hyperplasia: adaptation and prospective validation of...
Next Document: Compliance of drugstores with a national smoke-free law: A pilot survey.