Document Detail

Increased blood viscosity is associated with reduced renal function and elevated urinary albumin excretion in essential hypertensives without chronic kidney disease.
MedLine Citation:
PMID:  23154588     Owner:  NLM     Status:  Publisher    
Increased blood viscosity reduces blood flow and elevates vascular resistance in the cardiovascular system. The aim of this study was to elucidate how blood viscosity could affect renal function and eventually contribute to renal damage in essential hypertensives (EHT). In 164 untreated EHT without apparent renal damage (96 men, 56±12 years old, creatinine clearance 123±33 ml min(-1) per 1.73 m(2) and urinary albumin excretion 19±19 mg per day), blood and plasma viscosity was determined using a falling ball microviscometer. Blood viscosity correlated negatively with creatinine clearance (r=-0.185, P=0.018) and positively with urinary albumin excretion (r=0.253, P=0.001). This indicated that increased blood viscosity is associated with reduced renal function and worsening of albuminuria in EHT. Stepwise multiple regression analysis identified blood viscosity as an independent determinant of creatinine clearance (R(2)=0.058) and urinary albumin excretion (R(2)=0.216). In conclusion, increased blood viscosity may be a risk for development of renal disease in EHT.Hypertension Research advance online publication, 15 November 2012; doi:10.1038/hr.2012.172.
Hiroko Sugimori; Fumihiro Tomoda; Tsutomu Koike; Hiroko Kurosaki; Toshitaka Masutani; Maiko Ohara; Satoshi Kagitani; Hiroshi Inoue
Related Documents :
12797058 - Prognostic appraisal of success and failure in an in vitro fertilization program by tra...
14689538 - The reliability of virtual organ computer-aided analysis (vocal) for the semiquantifica...
2160988 - Transvaginal color doppler imaging.
1662458 - Action of acth in the luteal ovary.
12768578 - Method to determine in vivo the relaxation time t1 of hyperpolarized xenon in rat brain.
17226898 - Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscop...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  -     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The Second Department of Internal Medicine, University of Toyama, Toyama, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension...
Next Document:  Aliskiren vs. other antihypertensive drugs in the treatment of hypertension: a meta-analysis.