| Increased blood pressure variability in menopause. | |
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MedLine Citation:
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PMID: 18575158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood pressure variability represents an independent risk factor for cardiovascular diseases. To detect possible blood pressure variability changes from fertile to menopausal status, we enrolled consecutively 219 women: 104 fertile women (46.6 +/- 3.4 years) and 115 menopausal women (53.9 +/- 3.98 years). We evaluated for each patient the body mass index (BMI), 24 h, daytime, night-time systolic and diastolic mean blood pressure values and blood pressure variability data by means of an Ambulatory Blood Pressure Monitoring device. We found a significant higher mean age, body mass index, systolic and diastolic 24 h, day and night-time blood pressure variability in menopausal women when compared to fertile women. Age and BMI were significantly correlated to most blood pressure variability data with the Spearman Rank test. The multivariate logistic regression with dichotomic variables showed that the menopausal status is independently correlated to 24 h systolic (p < 0.0005) and diastolic (p < 0.05) variability, systolic (p < 0.05) and diastolic (p < 0.05) daytime pressure variability and systolic night-time pressure variability (p < 0.05). Furthermore, we found independent correlations between age 24 h systolic (p < 0.05) and night-time diastolic blood pressure variability (p < 0.05), while the BMI was indepententely correlated to BMI 24h diastolic (p < 0.01), daytime systolic (p < 0.01) and diastolic (p < 0.05) blood pressure variability. These data show a significant increase of blood pressure variability in menopausal women when compared to fertile women, even after exclusion of confounding factors, such as aging and BMI. Menopausal status, aging and BMI increase may all, independently, contribute to the enhanced blood pressure variability we found in menopausal women. |
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Authors:
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A Migneco; V Ojetti; M Covino; M Mettimano; M R Montebelli; A Leone; L Specchia; A Gasbarrini; L Savi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European review for medical and pharmacological sciences Volume: 12 ISSN: 1128-3602 ISO Abbreviation: Eur Rev Med Pharmacol Sci Publication Date: 2008 Mar-Apr |
Date Detail:
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Created Date: 2008-06-25 Completed Date: 2008-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717360 Medline TA: Eur Rev Med Pharmacol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 89-95 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Catholic University, Rome, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aging / physiology Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Body Mass Index* Case-Control Studies Circadian Rhythm / physiology Female Humans Logistic Models Menopause / physiology* Middle Aged Multivariate Analysis Prospective Studies |
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