Document Detail

Increased blood pressure following pupillary dilation with 2.5% phenylephrine hydrochloride in preterm infants.
MedLine Citation:
PMID:  7267230     Owner:  NLM     Status:  MEDLINE    
Heart rate and blood pressure changes following 0.5% tropicamide and 2.5% phenylephrine hydrochloride were evaluated in seven ill preterm infants (birth weight, 910 to 2,060 gm; gestational age, 26 to 36 weeks) during the first day of life. Each infant was monitored continuously for 30 minutes before and for 75 minutes after, instillation of the pupillary dilators. There were no significant changes in the heart rate, whereas a significant increase in systolic, diastolic, and mean arterial blood pressure was found. The increase in arterial blood pressure was detected at two minutes, peaked at eight minutes, and remained at significantly higher levels for 30 minutes after instillation. Because of the potential relationship between increased blood pressure and intraventricular hemorrhage, arterial blood pressure must be monitored during instillation of mydriatic drugs in the preterm infant.
B J Lees; L A Cabal
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  68     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects*
Drug Therapy, Combination
Heart Rate / drug effects
Infant, Newborn
Infant, Premature*
Mydriatics / adverse effects
Phenylephrine / adverse effects*
Pyridines / adverse effects*
Tropicamide / adverse effects*
Reg. No./Substance:
0/Mydriatics; 0/Pyridines; 1508-75-4/Tropicamide; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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