Document Detail

Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI.
MedLine Citation:
PMID:  12053125     Owner:  NLM     Status:  MEDLINE    
We investigated blood-brain barrier (BBB) permeability in white matter lesions of Binswanger's disease (BD) with contrast-enhanced MRI. Three subject groups were studied: 17 patients with BD and periventricular hyperintensities (PVH) on MRI, 10 patients with ischemic cerebrovascular events and with PVH but no dementia, and 14 age-matched control subjects without PVH. BBB permeability was quantified by calculation of T(1) change defined as [(T(1post) - T(1pre))/T(1pre)] x100, where T(1pre) and T(1post) represent the T(1) relaxation times before and after Gd-DTPA administration. T(1) change in PVH of BD patients significantly decreased in comparison with that observed in PVH of the nondemented patients and in normal white matter of the control subjects, but no significant T(1) change was observed between the PVH of the nondemented patients and normal white matter of the controls. There was a significant correlation between the Mini-Mental State Examination score and T(1) change for areas of PVH in BD. These results suggest that BBB permeability increases in areas of PVH in BD and that a BBB dysfunction is related to a progression of cognitive impairment.
Haruo Hanyu; Tetsuichi Asano; Yuriko Tanaka; Toshihiko Iwamoto; Masaru Takasaki; Kimihiko Abe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  14     ISSN:  1420-8008     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-07     Completed Date:  2002-07-26     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Blood-Brain Barrier*
Brain / metabolism*,  pathology
Capillary Permeability
Dementia, Vascular / diagnosis*,  metabolism
Gadolinium DTPA / diagnostic use,  pharmacokinetics
Image Enhancement
Magnetic Resonance Imaging
Reg. No./Substance:
80529-93-7/Gadolinium DTPA

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