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Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina--basal coronary artery tone in patients with variant angina.
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MedLine Citation:
PMID:  8703366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic and non-spastic sites. Thus, the purpose of this study was to assess the basal coronary artery tone and the responsiveness to acetylcholine (Ach) and ergonovine (Erg) in patients with variant angina. We compared the basal coronary artery tone and the constrictive responses to Ach and Erg between 31 patients (Group 1) with variant angina in whom spasm was provoked by the low doses of Ach (intracoronary 20 micrograms) or Erg(intravenous 50 micrograms) and 35 patients (Group 2) provoked by higher doses of Ach (intracoronary 100 micrograms) or Erg (intravenous cumulative dose of 350 micrograms), and 26 control subjects. Patients with variant angina in whom spasm was provoked by low doses of Ach or Erg, had a higher incidence of mixed disease, multi-vessel spasm and higher disease activity. The basal coronary artery tone at the spastic and nonspastic sites of spasm related artery was significantly more elevated in Group 1 than that in Group 2 (44 +/- 17 vs 14 +/- 11% and 26 +/- 14 vs 16 +/- 10% respectively, P < 0.05), but not in the nonspasm related artery, The magnitudes of vasoconstrictive responses to Ach and Erg at the nonspastic sites were also greater in Group 1 than those in Group 2 and the control groups (Ach; 40 +/- 20 vs 26 +/- 11, 27 +/- 12%: Erg; 37 +/- 18 vs 12 +/- 8, 13 +/- 10% respectively, P < 0.05). However, the basal coronary artery tone was not elevated at the spastic and nonspastic sites in Group 2 compared to the in control subjects. These findings suggest that the basal coronary artery tone is increased in patients with variant angina with higher disease activity at the spastic sites and nonspastic sites of the spasm-related artery, and this may be related to the occurrence of coronary artery spasm.
Authors:
S J Park; S W Park; J J Kim; J K Song; M K Hong; D H Kang; S S Cheong; C W Lee; J K Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  11     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-09-10     Completed Date:  1996-09-10     Revised Date:  2011-03-16    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  KOREA    
Other Details:
Languages:  eng     Pagination:  17-25     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology*
Angina Pectoris, Variant / physiopathology*
Coronary Vessels / drug effects*,  physiopathology
Dose-Response Relationship, Drug
Ergonovine / pharmacology*
Female
Humans
Male
Middle Aged
Nitroglycerin / pharmacology
Spasm / chemically induced,  physiopathology
Vasoconstriction / drug effects,  physiology
Vasoconstrictor Agents / pharmacology*
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin; 60-79-7/Ergonovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
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Print publication date: Month: 2 Year: 1996
Volume: 11 Issue: 1
First Page: 17 Last Page: 25
ID: 3053916
PubMed Id: 8703366

Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina--basal coronary artery tone in patients with variant angina.
S. J. Park
S. W. Park
J. J. Kim
J. K. Song
M. K. Hong
D. H. Kang
S. S. Cheong
C. W. Lee
J. K. Lee
Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.


Article Categories:
  • Research Article


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