| Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina--basal coronary artery tone in patients with variant angina. | |
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MedLine Citation:
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PMID: 8703366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic and non-spastic sites. Thus, the purpose of this study was to assess the basal coronary artery tone and the responsiveness to acetylcholine (Ach) and ergonovine (Erg) in patients with variant angina. We compared the basal coronary artery tone and the constrictive responses to Ach and Erg between 31 patients (Group 1) with variant angina in whom spasm was provoked by the low doses of Ach (intracoronary 20 micrograms) or Erg(intravenous 50 micrograms) and 35 patients (Group 2) provoked by higher doses of Ach (intracoronary 100 micrograms) or Erg (intravenous cumulative dose of 350 micrograms), and 26 control subjects. Patients with variant angina in whom spasm was provoked by low doses of Ach or Erg, had a higher incidence of mixed disease, multi-vessel spasm and higher disease activity. The basal coronary artery tone at the spastic and nonspastic sites of spasm related artery was significantly more elevated in Group 1 than that in Group 2 (44 +/- 17 vs 14 +/- 11% and 26 +/- 14 vs 16 +/- 10% respectively, P < 0.05), but not in the nonspasm related artery, The magnitudes of vasoconstrictive responses to Ach and Erg at the nonspastic sites were also greater in Group 1 than those in Group 2 and the control groups (Ach; 40 +/- 20 vs 26 +/- 11, 27 +/- 12%: Erg; 37 +/- 18 vs 12 +/- 8, 13 +/- 10% respectively, P < 0.05). However, the basal coronary artery tone was not elevated at the spastic and nonspastic sites in Group 2 compared to the in control subjects. These findings suggest that the basal coronary artery tone is increased in patients with variant angina with higher disease activity at the spastic sites and nonspastic sites of the spasm-related artery, and this may be related to the occurrence of coronary artery spasm. |
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Authors:
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S J Park; S W Park; J J Kim; J K Song; M K Hong; D H Kang; S S Cheong; C W Lee; J K Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Korean medical science Volume: 11 ISSN: 1011-8934 ISO Abbreviation: J. Korean Med. Sci. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-09-10 Completed Date: 1996-09-10 Revised Date: 2011-03-16 |
Medline Journal Info:
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Nlm Unique ID: 8703518 Medline TA: J Korean Med Sci Country: KOREA |
Other Details:
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Languages: eng Pagination: 17-25 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology* Angina Pectoris, Variant / physiopathology* Coronary Vessels / drug effects*, physiopathology Dose-Response Relationship, Drug Ergonovine / pharmacology* Female Humans Male Middle Aged Nitroglycerin / pharmacology Spasm / chemically induced, physiopathology Vasoconstriction / drug effects, physiology Vasoconstrictor Agents / pharmacology* Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 0/Vasodilator Agents; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin; 60-79-7/Ergonovine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Korean Med Sci Journal ID (pmc): jkms ISSN: 1011-8934 ISSN: 1598-6357 Publisher: Korean Academy of Medical Sciences |
Article Information Download PDF  Print publication date: Month: 2 Year: 1996 Volume: 11 Issue: 1 First Page: 17 Last Page: 25 ID: 3053916 PubMed Id: 8703366 |
| Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina--basal coronary artery tone in patients with variant angina. | |
| S. J. Park | |
| S. W. Park | |
| J. J. Kim | |
| J. K. Song | |
| M. K. Hong | |
| D. H. Kang | |
| S. S. Cheong | |
| C. W. Lee | |
| J. K. Lee | |
| Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea. |
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