Document Detail


Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis.
MedLine Citation:
PMID:  7583529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increasing evidence indicates that immune processes modulate atherogenesis. Oxidized LDL (Ox-LDL) is immunogenic, and autoantibodies recognizing epitopes of Ox-LDL have been described in plasma and in atherosclerotic lesions of several species. To determine whether the titer of such autoantibodies correlates with the extent of atherosclerosis, we followed the development of antibodies against malondialdehyde-lysine, an epitope of Ox-LDL, in two groups of LDL receptor-deficient mice for 6 months. One group was fed an atherogenic diet (21% fat and 0.15% cholesterol) that resulted in marked hypercholesterolemia and extensive aortic atherosclerosis; the other group was fed regular rodent chow (4% fat) that did not alter plasma cholesterol levels and induced minimal atherosclerosis. Autoantibody titers significantly increased over time in the group on the atherogenic diet, whereas they remained constant in the chow-fed group. When data from both groups were pooled, a significant correlation was found between the autoantibody titers and the extent of atherosclerosis (r = .61, P < .01). Autoantibody titers also correlated with plasma cholesterol levels (r = .48, P < .05). These results suggest that the rise in autoantibody titers to an epitope of Ox-LDL in this murine model is partially determined by the extent of atherosclerosis but could also be influenced by the degree of hypercholesterolemia or other factors that may influence lipid peroxidation.
Authors:
W Palinski; R K Tangirala; E Miller; S G Young; J L Witztum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  15     ISSN:  1079-5642     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-27     Completed Date:  1995-11-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1569-76     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of California, San Diego, La Jolla 92093-0682, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / pathology
Arteriosclerosis / chemically induced,  immunology*,  metabolism,  pathology
Autoantibodies / blood*
Cholesterol, Dietary
Disease Models, Animal
Epitopes / immunology
Lipid Peroxidation
Lipoproteins, LDL / immunology*,  metabolism
Mice
Receptors, LDL / deficiency*
Grant Support
ID/Acronym/Agency:
HL14197/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Cholesterol, Dietary; 0/Epitopes; 0/Lipoproteins, LDL; 0/Receptors, LDL

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