Document Detail

Increased augmentation index and central aortic blood pressure in osteoporotic postmenopausal women.
MedLine Citation:
PMID:  17676381     Owner:  NLM     Status:  MEDLINE    
Osteoporosis has been associated with cardiovascular disease. We found increased augmentation index, a measure of wave reflections and arterial stiffness, and central pressures in osteoporotic postmenopausal women. They also showed a higher estimated aortic pulse wave velocity, indicating a stiffer aorta. These changes may increase cardiovascular risk in postmenopausal osteoporosis. INTRODUCTION: Evidence suggests a link between osteoporosis and cardiovascular disease. We investigated whether augmentation index (AIx), a measure of pulse wave reflections and arterial stiffness, is increased and related to the osteoprotegerin (OPG)/receptor activator of nuclear factor-kappa B ligand (RANKL) system in postmenopausal osteoporosis. METHODS: AIx and central aortic haemodynamics were assessed using pulse wave analysis in 182 cardiovascular disease-free osteoporotic postmenopausal women and in 160 controls. Statistical analysis was performed by unpaired t test, Mann-Whitney test, Spearman's correlation coefficient, and multivariate linear regression analysis. RESULTS: AIx (37.2 +/- 7.0 vs. 29.6 +/- 9.2 %, P < 0.0001) and central aortic systolic (117.5 +/- 12.1 vs. 111.4 +/- 12.2 mmHg, P < 0.0001) and pulse (40.5 +/- 10.3 vs. 36.4 +/- 8.1 mmHg, P = 0.0007) pressures were significantly higher in osteoporotic patients than in controls. The estimated aortic pulse wave velocity (PWV) was also significantly higher in the osteoporotic group. In multivariate analysis for osteoporotic patients, femoral neck and lumbar spine bone mineral density T scores were independent negative predictors of AIx (P < 0.0001). AIx was not correlated with serum levels of OPG and RANKL. CONCLUSIONS: Osteoporotic postmenopausal women show increased AIx and central aortic pressures, and a higher estimated aortic PWV, indicating a stiffer aorta. Such alterations may increase cardiovascular risk in postmenopausal osteoporosis.
R A Mangiafico; C Alagona; P Pennisi; N Parisi; M Mangiafico; F Purrello; C E Fiore
Publication Detail:
Type:  Journal Article     Date:  2007-08-04
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  19     ISSN:  0937-941X     ISO Abbreviation:  Osteoporos Int     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Department of Internal Medicine, University of Catania, Catania, Italy.
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MeSH Terms
Aorta / physiopathology*
Blood Flow Velocity / physiology
Blood Pressure / physiology*
Bone Density
Case-Control Studies
Femur Neck / chemistry
Lumbar Vertebrae / chemistry
Middle Aged
Osteoporosis, Postmenopausal / physiopathology*
Osteoprotegerin / blood
Pulsatile Flow / physiology*
RANK Ligand / blood
Vascular Resistance / physiology*
Reg. No./Substance:
0/Osteoprotegerin; 0/RANK Ligand

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