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Increased asymmetric dimethylarginine and enhanced inflammation are associated with impaired vascular reactivity in women with endometriosis.
MedLine Citation:
PMID:  21880316     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Enhanced inflammatory responses which may inhibit vascular reactivity, are associated with endometriosis development. Asymmetric dimethylarginine (ADMA), an inhibitor of endogenous nitric oxide synthase, is also implicated in endothelial dysfunction. We aimed to determine whether plasma ADMA and systemic inflammation are associated with endothelial function in women with endometriosis. METHODS: We evaluated 41 women with and 28 women without endometriosis. Plasma levels of lipids and inflammatory markers such as high sensitive-C reactive protein (hs-CRP), serum amyloid protein A (SAA), and interleukin-6 (IL-6) were measured in the two groups. We also measured levels of ADMA and symmetric dimethylarginine (SDMA). High-resolution ultrasonography measured flow-mediated vasodilation (FMD) to assess vasodilatory responses. RESULTS: FMD was significantly lower in women with endometriosis compared to those without endometriosis (8.39±0.43% vs 10.79±0.54%, P=0.001). While plasma lipid levels did not differ significantly between groups, levels of AMDA, but not SDMA, were significantly higher in women with endometriosis (409.7±10.1pmol/L vs 383.0±48.3pmol/L, P=0.04). Inflammatory markers were also significantly higher in these women (hs-CRP: 1053.3±252.0ng/mL vs 272.0±83.3ng/mL, P=0.02; SAA: 8.00±1.53μg/mL vs 3.82±0.42μg/mL, P=0.04; IL-6: 2.73±0.75pg/mL vs 1.05±0.60pg/mL, P=0.04). FMD was negatively correlated with plasma levels of ADMA (r=-0.37, P=0.01) and log hs-CRP (r=-0.34, P=0.01). CONCLUSION: Increased plasma ADMA levels and enhanced inflammation are associated with inhibited endothelial function in women with endometriosis.
Authors:
Shoko Kinugasa; Koichi Shinohara; Akihiko Wakatsuki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-10
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
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