| Increased arterial wall stiffness in primary aldosteronism in comparison with essential hypertension. | |
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MedLine Citation:
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PMID: 16942932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aldosterone has been shown to substantially contribute to the accumulation of collagen fibers and growth factors in the arterial wall, which can increase wall stiffness. This study aimed at comparing arterial stiffness between patients with primary aldosteronism (PA), essential hypertension (EH), and normotensive controls using carotid-femoral pulse wave velocity (PWV) and central augmentation index (AI). METHODS: Thirty-six patients with confirmed PA, 28 patients with EH, and 20 normotensive subjects were investigated by Sphygmocor applanation tonometer. RESULTS: The office blood pressure (BP) at the time of the measurement (PA 167+/-34/92+/-12 mm Hg; EH 166+/-19/91+/-10 mm Hg), age, body mass index (BMI), cholesterol, triglyceride, blood glucose levels were comparable between PA and EH groups. The patients with PA had significantly higher PWV than the EH patients and control subjects (9.8+/-2.6 m/sec v 7.5+/-1.0 m/sec v 5.9+/-0.7 m/sec, respectively; all mutual differences P<.001). The difference in PWV between PA and EH remained statistically significant also after the adjustment for all clinical variables including 24-h BP using multivariate analysis (P=.001). CONCLUSIONS: Arterial wall stiffness is independently increased in PA compared to EH. This could be caused by the deleterious effects of aldosterone excess (potentially modulated by hypernatremia) on the fibrosis and remodeling of the arterial wall. |
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Authors:
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Branislav Strauch; Ondrej Petrák; Dan Wichterle; Tomás Zelinka; Robert Holaj; Jirí Widimský |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hypertension Volume: 19 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-31 Completed Date: 2007-05-09 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 909-14 Citation Subset: IM |
Affiliation:
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3rd Department of Internal Medicine, lst Medical School, Charles University and General University Hospital, Prague, Czech Republic. strauch@volny.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Arteries / physiopathology* Biological Markers / blood Blood Flow Velocity Blood Pressure Case-Control Studies Female Heart Rate Humans Hyperaldosteronism / physiopathology* Hypertension / physiopathology* Male Middle Aged Pulse Vascular Resistance* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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