Document Detail


Increased arterial stiffness in female-to-male transsexuals treated with androgen.
MedLine Citation:
PMID:  18834347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Female-to-male (FTM) transsexuals are treated with long-term and high-dose androgen. Although androgen is known to affect the cardiovascular system, vascular function in FTM transsexuals has not been fully elucidated. The aim of this study was to evaluate the arterial stiffness in FTM transsexuals treated with androgen. METHODS: We evaluated the arterial stiffness in 111 FTM transsexuals (63 untreated FTM transsexuals and 48 FTM transsexuals treated with androgen) using a volume-plethysmographic apparatus equipped with a multi-element applanation tonometry sensor. RESULTS: There were no significant differences in age, body mass index and heart rate between the untreated FTM transsexuals and those treated with androgen. The systolic and diastolic blood pressures in FTM transsexuals treated with androgen were significantly higher than those in untreated FTM transsexuals. The level of brachial-ankle pulse wave velocity in FTM transsexuals treated with androgen (1202.8+/-138.2 cm/s) was significantly higher than that in untreated FTM transsexuals (1080.2+/-113.7 cm/s) while there was no significant difference in the carotid augmentation index between untreated FTM transsexuals and those treated with androgen. CONCLUSIONS: Long-term and high-dose administration of androgen is likely to cause increased arterial stiffness in FTM transsexuals. To prevent atherosclerosis and cardiovascular events, a periodic checkup and pharmacological therapies for hypertension should be tailored on an individual basis.
Authors:
Yayoi Emi; Miwa Adachi; Aiko Sasaki; Yoshio Nakamura; Mikiya Nakatsuka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  34     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  890-7     Citation Subset:  IM    
Affiliation:
Graduate School of Health Sciences, Okayama University, Okayama-city, Okayama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects,  physiology
Brachial Artery / drug effects*,  physiopathology
Estradiol / blood
Female
Heart Rate / drug effects,  physiology
Humans
Plethysmography
Testosterone / administration & dosage,  adverse effects*
Transsexualism / blood,  physiopathology,  surgery*
Young Adult
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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