Document Detail

Increased arterial stiffness in elderly female diabetic peritoneal dialysis patients.
MedLine Citation:
PMID:  18997457     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Arterial stiffness is a major risk factor for cardiovascular and all-cause mortality in patients with end-stage renal disease. It has been reported that female and elderly diabetes mellitus (DM) patients treated with peritoneal dialysis (PD) had a higher risk of death. However, the underlying mechanism remains unknown. The present study tried to investigate whether older female DM patients have increased arterial stiffness. METHODS: One hundred and eighty-one continuous ambulatory PD patients in a single center were enrolled. On enrollment, demographic data were collected. Carotid-femoral pulse wave velocities (PWV) were checked at the same time. RESULTS: As expected, age had a significant impact on PWV both in DM and non-DM patients. There was no significant difference in PWV between male and female patients under the age of 50. No significant difference in PWV was found between male and female non-DM patients over the age of 50. However, the comparison of PWV reached statistical significance between male and female DM patients over the age of 50 (12.44 +/- 1.83 m/s vs. 13.56 +/- 1.86 m/s, p < 0.05). CONCLUSIONS: Our study showed that female DM patients over the age of 50 had the highest PWV as compared to other patient groups. Increased arterial stiffness might have contributed to the worst outcome of this population on PD treatment.
Yue Gu; Li-Tao Cheng; Jing Zeng; Tao Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-07
Journal Detail:
Title:  American journal of nephrology     Volume:  29     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  414-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 S. Karger AG, Basel.
Division of Nephrology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, China.
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MeSH Terms
Age Factors
Arteries / physiopathology*
China / epidemiology
Diabetes Complications / physiopathology*
Kidney Failure, Chronic / etiology,  mortality,  physiopathology
Middle Aged
Peritoneal Dialysis
Sex Factors

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