| Increased arterial stiffness in children treated with anthracyclines for malignant disease. | |
| | |
MedLine Citation:
|
PMID: 21755708 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Survivors of childhood cancer have a significantly higher late morbidity and mortality from cardiovascular diseases. The aim of this study was to determine whether anthracyclines used in childhood could increase arterial stiffness, a well-known independent predictor of cardiovascular diseases. The study included 53 children and adolescents aged 6-20 years having completed anthracycline treatment for a malignant disease according to various protocols at least a year before. The patients were free from clinical or laboratory signs of the underlying disease or cardiac disease. Control group consisted of 45 age- and sex-matched healthy children. Arterial stiffness was determined by measuring aortic pulse wave velocity (PWVao) using oscillometric method (Arteriograph TensioMed device). PWVao value was significantly increased (6.24 +/- 1.34 m/s vs. 5.42 +/- 0.69 m/s; p < 0.001) in patients having received anthracyclines as compared to control group. Increased arterial stiffness was present irrespective of the following parameters: age, sex, body mass index, systolic and diastolic blood pressure, mean arterial pressure and heart rate. It is possible that the effect of anthracycline on increased cardiovascular morbidity and mortality in long-term childhood cancer survivors is associated not only with cardiotoxicity, but also with increased arterial stiffness. |
| | |
Authors:
|
Vesna Herceg-Cavrak; Vladimir Ahel; Maja Batinica; Lana Matec; Danijel Kardos |
Related Documents
:
|
2923048 - Angiographic observations and clinical relevance of coronary thrombus in unstable angin... 6986748 - John hunter, angina pectoris and medical education. 6125128 - Coronary artery spasm following coronary artery revascularization. 2112998 - Nitroglycerin-resistant coronary spasm treated with intracoronary linsidomine chlorhydr... 16001138 - A case of aortopulmonary window simulating common arterial trunk presented at the age o... 10884468 - Three-dimensional ultrasound observation of carotid artery plaque ulceration. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Collegium antropologicum Volume: 35 ISSN: 0350-6134 ISO Abbreviation: Coll Antropol Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-07-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8003354 Medline TA: Coll Antropol Country: Croatia |
Other Details:
|
Languages: eng Pagination: 389-95 Citation Subset: IM |
Affiliation:
|
University of Zagreb, "Sestre milosrdnice" University Hospital Center, Zagreb Children's Hospital, Department of Pediatrics, Cardiology Unit, Zagreb, Croatia. vherceg@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of the C609T polymorphism of NQO1 gene in South Croatian patients with hematological malign...
Next Document: Clinical characteristics of patients with spondyloarthritides and HLA-B27 positive antigen.