Document Detail


Increased arterial stiffness in children with Williams syndrome and normal blood pressure.
MedLine Citation:
PMID:  20729725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: High blood pressure (BP), probably related to the loss of arterial elasticity, frequently arises in patients affected by Williams syndrome (WS). This study aimed at proving that arterial compliance, evaluated by automated recording of the QKd interval, was lower even in young normotensive patients with WS than in a control group of healthy individuals with normal BP values.
METHODS: Twenty-nine children (12.8±4.1 years) suffering from WS (both hypertensive and normotensive) were enroled. Arterial stiffness was measured by the standardized noninvasive QKd100-60 method. A 24-h ambulatory BP monitoring and a transthoracic echocardiography were also performed.
RESULTS: The WS hypertensive children showed significant differences in ambulatory BP monitoring profile in comparison with WS normotensive individuals (systolic BP: P<0.0001, diastolic BP: P<0.0001, mean BP: P<0.0001). All of the 29 WS patients in the study showed disadvantageous differences in QKd100-60 value (P<0.0001) compared with control group. No statistical significant differences were found in QKd100-60 value between the hypertensive and normotensive children affected by WS (P=not significant).
CONCLUSION: Our data show that arterial stiffness is increased in WS, even in patients with normal BP. It might signify a poor future outcome even in those WS patients with apparently no severe cardiovascular involvement.
Authors:
Pier Paolo Bassareo; Giuseppe Mercuro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  15     ISSN:  1473-5725     ISO Abbreviation:  Blood Press Monit     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2011-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular and Neurological Sciences, University of Cagliari, Policlinico Universitario, Monserrato, Cagliari, Italy. piercard@inwind.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Child
Echocardiography
Humans
Vascular Resistance*
Williams Syndrome / physiopathology*

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