Document Detail


Increased apoptosis of circulating T cells in myelodysplastic syndromes.
MedLine Citation:
PMID:  17485109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of T cell lymphopenia in myelodysplastic syndromes (MDS) is unknown. We investigated apoptosis in freshly isolated and cultured lymphocytes; the latter were used to detect cells not yet apoptotic but destined for apoptosis. Apoptosis increased in both fresh and cultured T cells in MDS compared with those from healthy controls. Furthermore, in lymphopenic MDS patients the lymphocyte count correlated negatively with the degree of T cell apoptosis. MDS T cells showed increased Fas expression. However, in MDS but not in controls, the degree of T cell apoptosis was independent of the Fas expression level, and exogenous anti-Fas antibodies did not modulate T cell apoptosis. Mechanisms other than the Fas-Fas ligand pathway may induce T cell apoptosis in MDS.
Authors:
Yumiko Shioi; Hideto Tamura; Norio Yokose; Chikako Satoh; Kazuo Dan; Kiyoyuki Ogata
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Publication Detail:
Type:  Journal Article     Date:  2007-05-07
Journal Detail:
Title:  Leukemia research     Volume:  31     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1641-8     Citation Subset:  IM    
Affiliation:
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antibodies / pharmacology
Antigens, CD95 / analysis*,  immunology
Apoptosis*
Case-Control Studies
Humans
Lymphocyte Count
Lymphopenia / etiology*
Middle Aged
Myelodysplastic Syndromes / complications*
T-Lymphocytes / pathology*
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antigens, CD95

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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