Document Detail

Increased aortic wall stiffness associated with low circulating fetuin A and high C-reactive protein in predialysis patients.
MedLine Citation:
PMID:  19602903     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Vascular calcification and arterial stiffening are cardiovascular risk factors among chronic kidney disease (CKD) patients. The aim of the study was to analyze relationships between inflammatory markers, fetuin A and arterial wall stiffness in CKD patients in the predialysis period and on maintenance dialysis. METHODS: Serum C-reactive protein (hs-CRP), fetuin A, interleukin 6 (IL-6) and other classical markers of atherosclerosis were measured in a group of 155 CKD patients (77 on hemodialysis, HD, 29 on peritoneal dialysis, 49 in CKD stage 5 in the predialysis period) and in 30 healthy volunteers. The aortic pulse wave velocity (aoPWV) was recorded using a tonometric method. RESULTS: The aoPWV, serum hs-CRP and IL-6 were higher and fetuin A levels were lower in all CKD groups than in controls. In multiple regression analysis, the age appeared as the strongest, independent factor increasing arterial wall stiffness in all investigated groups, including controls, whereas the association of aoPWV with IL-6 and fetuin A remained significant only in HD patients. CONCLUSIONS: Aortic wall stiffness is higher in CKD patients than in controls, and it already develops in the predialysis period. Age is the principal determinant of arterial wall stiffness also in CKD patients. The acceleration of arterial wall stiffness in CKD is associated with additional factors, i.e. fetuin A deficiency and higher CRP and IL-6.
Tomasz Porazko; Jakub Kuźniar; Mariusz Kusztal; Tomasz J Kuźniar; Wacław Weyde; Magdalena Kuriata-Kordek; Marian Klinger
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2009-07-14
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  113     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-24     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c81-7     Citation Subset:  IM    
Department of Nephrology and Transplantation Medicine, Wrocław Medical University, Wrocław, Poland.
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MeSH Terms
Aorta / physiopathology*
Blood Proteins / metabolism*
C-Reactive Protein / metabolism*
Elastic Modulus
Kidney Failure, Chronic / physiopathology*,  prevention & control
Middle Aged
Renal Dialysis
Reg. No./Substance:
0/Blood Proteins; 0/alpha2HS glycoprotein; 9007-41-4/C-Reactive Protein

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