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Increased aortic stiffness elevates pulse and mean pressure and compromises endothelial function in Wistar rats.
MedLine Citation:
PMID:  25038146     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An increase in pulse pressure (PP) is highly associated with hypertension. The goal of this study was to determine the effect of increased aortic stiffness on PP and endothelial dysfunction as precursors to hypertension. A rat model of suddenly increased aortic stiffness by use of a non-constrictive restraint (glue coating) on aortic surface was created to investigate the change of PP and mean arterial pressure (MAP). Group I (n=16) underwent aorta restraint for 4 weeks. Group II (n=12) underwent aorta restraint for 4 weeks, but were allowed to recover for 4 weeks after restraint removal to evaluate reversibility. The aortic and peripheral endothelial function was assessed by acetylcholine-stimulated endothelium-dependent vasodilation. The level of nitrate/nitrite (NOx), endothelin-1 (ET-1) and prostacyclin (PGI2) was measured in the serum and artery tissue. We found that aortic stiffening causes a significant increase in PP and MAP (P<0.05). The endothelial function were markedly blunted (P<0.05) in both aorta and small peripheral artery. After removal of the restraint, the impaired endothelium function persisted in the aorta likely due to irreversible deterioration of aortic wall, but was partially restored in peripheral artery. The endothelial dysfunction was associated with a decrease in NOx and PGI2 (P<0.05) and an increase in ET-1 (P<0.05). Our results show that aortic stiffening results in widening of PP which affected endothelium function through changes in synthesis of NOx, ET-1 and PGI2. These findings suggest that increased aortic stiffness may be a cause of increased PP and hypertension.
Authors:
Xiaomei Guo; Xiao Lu; Junrong Yang; Ghassan S Kassab
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-18
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Heart and Circulatory Physiology.
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