Document Detail

Increased aortic intima-media thickness is related to lipid profile in newborns with intrauterine growth restriction.
MedLine Citation:
PMID:  16601348     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Low birth-weight is known to be associated with an increase in cardiovascular risk similar to that seen with major environmental risk factors, such as cigarette smoking or hypertension. Much epidemiological evidence has linked low birth-weight with hypertriglyceridaemia. METHOD: We measured aortic wall thickness by ultrasonography and lipid profile in 40 newborn babies with intrauterine growth restriction and 40 controls. RESULTS: Maximum and mean aortic intima-media thickness were significantly higher in the babies with intrauterine growth retardation (0.58 +/- 0.06, 0.52 +/- 0.03 mm, respectively) than in controls (0.44 +/- 0.05, 0.40 +/- 0.03 mm, p < 0.0001, p < 0.0001, respectively), more so after adjustment for birth-weight (maximum intima-media thickness: 0.23 +/- 0.03 mm/kg vs. 0.12 +/- 0.02 mm/kg, p < 0.0001; mean intima-media thickness: 0.21 +/- 0.02 mm/kg vs. 0.11 +/- 0.01 mm/kg, p < 0.0001). Serum triglyceride levels were significantly higher in the intrauterine growth retardation group (48.9 +/- 14.8 mg/dl) compared with the control group (32.5 +/- 9.8 mg/dl, p < 0.0001). The mean body mass index, prepregnancy weight, weight gain during pregnancy, maternal LDL cholesterol level and, height of the mothers were significantly lower in the intrauterine growth retardation group compared with the control group. For maximum aIMT, significant associations included the ponderal index (p = <0.01), length (p = 0.01) and serum triglyceride levels of infants (p = 0.02). CONCLUSION: Newborn babies with growth restriction have significant maximum aortic thickening with hypertriglyceridaemia, suggesting that prenatal events might predispose to later cardiovascular risk.
Esad Koklu; Selim Kurtoglu; Mustafa Akcakus; Selmin Koklu; Derya Buyukkayhan; Hakan Gumus; Ali Yikilmaz
Related Documents :
17585098 - Protein metabolism in preterm infants with particular reference to intrauterine growth ...
7166598 - Eye measurements in preterm and term newborn infants.
7380118 - A longitudinal study of very low-birthweight infants. iii: distance growth at eight yea...
18217438 - Weight variation by sex and nature of risk factors in high-risk infants: an evolutionar...
3234608 - Development of the eeg between 30 and 40 weeks gestation in normal and alcohol-exposed ...
20092418 - Maternal mortality trend in south east nigeria: less than a decade to the millennium de...
Publication Detail:
Type:  Journal Article     Date:  2006-04-05
Journal Detail:
Title:  Hormone research     Volume:  65     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-09     Completed Date:  2006-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  269-75     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Department of Neonatology and Paediatric Endocrinology and Metabolism, Erciyes University, School of Medicine, Kayseri, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta / pathology*,  ultrasonography
Case-Control Studies
Cholesterol / blood
Fetal Growth Retardation / blood,  pathology*
Hypertriglyceridemia / pathology*
Infant, Newborn
Infant, Small for Gestational Age
Triglycerides / blood
Reg. No./Substance:
0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of imatinib mesylate on the contractility of isolated rabbit myometrial strips.
Next Document:  Sensitization to Lolium multiflorum grass pollen in pollinosis patients: evaluation of allergenic fr...