Document Detail

Increased antisecretory factor reduces vertigo in patients with Ménière's disease: a pilot study.
MedLine Citation:
PMID:  15051128     Owner:  NLM     Status:  MEDLINE    
It has been hypothesized that the symptoms of vertigo in patients with Ménière's disease somehow are related to impaired production and/or transport of endolymph. Antisecretory factor (AF) is a protein known to affect transport processes in the intestine and it has been shown that intake of specially processed cereals (SPC) can increase endogenous AF synthesis. In a prospective open pilot study, 24 patients with severe Ménière's disease (functional level scale 5-6 according to the criteria of AAO-HNS) received SPC for 14-30 days. AF levels in plasma increased by 83% in 20 of the 24 patients studied. The attacks of rotatory vertigo were reduced, to final AAO-HNS functional level scale 1-3, in 12 patients and in three of these hearing was normalized. Twelve patients had no or minor effects of the treatment. The correlation between AF activity after treatment and the final AAO-HNS functional level scale was -0.65, P<0.001. Studies in rats using immunohistochemistry methods showed that AF was localized to the cochlea and the vestibule of the inner ear. The present results suggest that AF might be a new regulator of the endolymph.
P Hanner; E Jennische; S Lange; I Lönnroth; B Wahlström
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hearing research     Volume:  190     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-10-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Department of Audiology, Sahlgrenska University Hospital, Göteborg University, S-413 45 Göteborg, Sweden.
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MeSH Terms
Aged, 80 and over
Auditory Threshold
Ear, Inner / chemistry
Food, Formulated*
Meniere Disease / complications,  diet therapy*,  metabolism
Middle Aged
Neuropeptides / analysis,  biosynthesis*,  blood
Pilot Projects
Prospective Studies
Vertigo / diet therapy*,  etiology,  metabolism
Reg. No./Substance:
0/Neuropeptides; 0/antisecretory factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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