Document Detail


Increased anal resting pressure and rectal sensitivity in Crohn's disease.
MedLine Citation:
PMID:  14668596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Anal pathology occurs in 20 to 80 percent of patients with Crohn's disease in which abscesses, fistulas, and fissures account for considerable morbidity. The etiology is not clearly defined, but altered anorectal pressures may play a role. This study was designed to investigate anorectal physiologic conditions in patients with Crohn's disease compared with healthy controls. METHODS: Twenty patients with Crohn's disease located in the ileum (n = 9) or the colon (n = 11) without macroscopic proctitis or perianal disease were included. All were subjected to rectal examination, anorectal manometry, manovolumetry, and rectoscopy. Comparison was made with a reference group of 173 healthy controls of whom 128 underwent anorectal manometry, 29 manovolumetry, and 16 both examinations. RESULTS: Maximum resting pressure and resting pressure area were higher in patients than in controls (P = 0.017 and P = 0.011, respectively), whereas maximum squeeze pressure and squeeze pressure area were similar. Rectal sensitivity was increased in patients expressed as lower values both for volume and pressure for urge (P = 0.013 and P = 0.014, respectively) as well as maximum tolerable pressure (P = 0.025). CONCLUSIONS: This study demonstrates how patients with Crohn's disease without macroscopic proctitis have increased anal pressures in conjunction with increased rectal sensitivity. This may contribute to later development of anal pathology, because increased intra-anal pressures may compromise anal circulation, causing fissures, and also discharging of fecal matter into the perirectal tracts, which may have a role in infection and fistula development.
Authors:
Peter Andersson; Gunnar Olaison; Olof Hallböök; Bernt Boeryd; Rune Sjödahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  46     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-11     Completed Date:  2004-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1685-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, Division of Colorectal Surgery, University Hospital, University of Linköping, S-581 85 Linköping, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Abscess / etiology
Adult
Aged
Anal Canal / pathology,  physiology*
Case-Control Studies
Crohn Disease / complications*
Female
Fissure in Ano / etiology*,  physiopathology
Humans
Male
Manometry
Middle Aged
Pressure
Rectal Fistula / etiology*,  physiopathology
Rectum / pathology,  physiology*
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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