| Increased airway mucins after cardiopulmonary bypass associated with postoperative respiratory complications in children. | |
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MedLine Citation:
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PMID: 15052191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Airway mucins may play an important role in the mechanism of respiratory complications after cardiopulmonary bypass in infants and children. Our aim was to measure airway mucin levels before and after cardiopulmonary bypass and to determine whether changes in mucin levels were associated with the development of respiratory complications. METHODS: Airway glycoprotein and mucins (MUC5AC, MUC5B, and MUC2) in serial small-volume airway lavage samples from 39 young children who underwent cardiac operations with cardiopulmonary bypass were measured by slot-blot assay with specific antimucin peptide antibodies. The relationship between mucin changes and post-cardiopulmonary bypass respiratory complications was investigated. Airway lavage samples were also collected from 11 children before and after operation without cardiopulmonary bypass, and changes in mucin levels were compared with those in subjects who underwent cardiopulmonary bypass. Airway lavage sample DNA was also measured to investigate the relationship between mucin changes and lung injury. RESULTS: Glycoprotein, MUC5AC, and MUC5B levels were significantly increased after cardiopulmonary bypass (P <.001) whereas MUC2 level was not. Children with respiratory complications showed significantly higher glycoprotein and MUC5AC levels than did children without respiratory complications before and after cardiopulmonary bypass (P <.05). Increase of total mucin (MUC5AC, MUC5B, and MUC2) during cardiopulmonary bypass showed positive correlation with DNA increase during cardiopulmonary bypass (r = 0.73), PaCO(2) (r = 0.62) and alveolar-arterial oxygen difference (r = 0.55) immediately after cardiopulmonary bypass. Increase of total mucin was associated with postoperative respiratory complications and their severity. There were no significant changes detected in airway mucin during operations without cardiopulmonary bypass. CONCLUSIONS: Airway mucins were increased during cardiopulmonary bypass, and this increase was associated with markers of lung injury after cardiopulmonary bypass and with the development of postoperative respiratory complications. |
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Authors:
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Hajime Imura; Heather P Duncan; Anthony P Corfield; Neil Myerscough; Massimo Caputo; Gianni D Angelini; Andrew R Wolf; A John Henderson |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 127 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-30 Completed Date: 2004-06-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 963-9 Citation Subset: AIM; IM |
Affiliation:
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Bristol Heart Institute, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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analysis Bronchoalveolar Lavage Fluid / chemistry Cardiac Surgical Procedures Cardiopulmonary Bypass* Child Child Welfare Child, Preschool Glycoproteins / metabolism Great Britain Heart Defects, Congenital / metabolism, surgery Humans Infant Infant Welfare Mucins / classification, metabolism* Oxygen / blood Postoperative Complications / etiology*, metabolism* Postoperative Period Respiratory Distress Syndrome, Adult / etiology*, metabolism* Respiratory Mucosa / metabolism Severity of Illness Index Statistics as Topic Time Factors Trachea / metabolism* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Glycoproteins; 0/Mucins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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