Document Detail

Increased airway leukotriene levels in infants with severe bronchopulmonary dysplasia.
MedLine Citation:
PMID:  2154089     Owner:  NLM     Status:  MEDLINE    
The sulphidopeptide leukotrienes (C4, D4, and E4) are potent airway constrictors that have been detected in the airways of infants with pulmonary hypertension and viral infections. The present study was undertaken to test the hypothesis that leukotrienes in tracheal lavage fluid are elevated in bronchopulmonary dysplasia. Twenty-six intubated infants (10 with bronchopulmonary dysplasia, 9 with hyaline membrane disease, and 7 normal controls) had tracheal lavage leukotriene levels determined by radioimmunoassay. Lavage fluid cell counts (alveolar macrophages) and leukotriene levels were significantly increased in infants with severe bronchopulmonary dysplasia. The increased concentration of leukotrienes seen in the infants with bronchopulmonary dysplasia would suggest a possible role for these compounds in the pathophysiology of this disease.
R Mirro; W Armstead; C Leffler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  144     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-15     Completed Date:  1990-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  160-1     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Tennessee, Memphis.
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MeSH Terms
Bronchopulmonary Dysplasia / metabolism*
Hyaline Membrane Disease / metabolism
Infant, Newborn
Leukotriene E4
SRS-A / analogs & derivatives,  analysis*
Trachea / metabolism*
Reg. No./Substance:
0/SRS-A; 75715-89-8/Leukotriene E4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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