Document Detail

Increased activation of 2',3'-dideoxycytidine by acivicin.
MedLine Citation:
PMID:  8060335     Owner:  NLM     Status:  MEDLINE    
The effect of acivicin (ACV) on cell growth, cell cycle progression, and intracellular accumulation of 2',3'-dideoxycytidine (ddC) was examined. Treatment of H9 cells with ACV (1 microM) plus ddC (25 microM) for 24 hrs inhibited cell growth to 74 +/- 7%, arrested cells in the S phase, and increased the cellular ddC accumulation to 195-208% of control. The concentrations of ddCTP, the active form of ddC, was increased 3-4 fold in ACV treated cells.
R P Agarwal
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  202     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-09-12     Completed Date:  1994-09-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1524-9     Citation Subset:  IM    
Department of Medical Oncology, University of Miami School of Medicine, FL 33136.
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MeSH Terms
Cell Cycle / drug effects
Cell Line
Drug Synergism
Isoxazoles / pharmacology*
Zalcitabine / metabolism*,  pharmacology
Grant Support
Reg. No./Substance:
0/Isoxazoles; 52583-41-2/acivicin; 7481-89-2/Zalcitabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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