| Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat. | |
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MedLine Citation:
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PMID: 18842745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Visceral hypersensitivity and symptom severity in Irritable Bowel Syndrome (IBS) are both exacerbated by stress. The eye-blink startle response represents a noninvasive measure of central defensive responding. Evidence for central hyperexcitability was studied in IBS patients by examining potentiation of the startle reflex to a nociceptive threat. METHODS: Acoustic startle responses were examined in female IBS patients (n = 42) and healthy controls (n = 22) during cued periods in which an aversive abdominal or biceps stimulation was impossible (safe), possible (imminent threat) or anticipated (period just before the imminent threat), and during a threatening context (muscle stimulation pads attached but no cues for stimulation). RESULTS: Both groups showed potentiation of startle responses during the imminent threat condition compared with both the anticipation and safe conditions. Compared with controls, IBS subjects showed significantly larger startle responses during anticipation and imminent threat conditions after receiving an initial aversive stimulation. There were no group differences during the context threat manipulation. Moreover, in IBS patients but not controls, higher neuroticism was associated with larger startle responses during safe and anticipation conditions but not imminent threat, whereas anxiety symptoms were negatively associated with startle magnitude during imminent threat. CONCLUSIONS: Female IBS patients show increased startle responses to threat of aversive stimulation at both abdominal and nonabdominal sites compared with controls. The data represent the first demonstration of altered threat potentiated startle in a functional pain condition and provide support for the use of these paradigms in further evaluation of affective mechanisms in these disorders. |
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Authors:
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Bruce D Naliboff; Allison M Waters; Jennifer S Labus; Lisa Kilpatrick; Michelle G Craske; Lin Chang; Hideki Negoro; Hana Ibrahimovic; Emeran A Mayer; Edward Ornitz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-10-08 |
Journal Detail:
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Title: Psychosomatic medicine Volume: 70 ISSN: 1534-7796 ISO Abbreviation: Psychosom Med Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-16 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
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Languages: eng Pagination: 920-7 Citation Subset: IM |
Affiliation:
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Center for Neurobiology of Stress, Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, California, USA. naliboff@ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Muscles
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physiopathology* Acoustic Stimulation Adult Anxiety / physiopathology, psychology Arousal / physiology* Blinking / physiology Colon, Sigmoid / physiopathology* Cues Electric Stimulation Electromyography Electrooculography Fear / physiology* Female Humans Irritable Bowel Syndrome / physiopathology*, psychology Isometric Contraction / physiology Nociceptors / physiology Pain Threshold / physiology Startle Reaction / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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NR007768/NR/NINR NIH HHS; P50 DK64539/DK/NIDDK NIH HHS; R24 AT002681/AT/NCCAM NIH HHS |
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