| Increased acid excretion in kidney stone formers with essential hypertension. | |
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MedLine Citation:
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PMID: 18715964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although several studies have reported that kidney stone disease and hypertension are associated, the link between the two conditions has not been identified. This study investigated urinary excretion of different solutes, particularly citrate and acids, in kidney stone formers and examined their association with high blood pressure. METHODS: The retrospective study included 234 consecutive subjects, aged 47.0 +/- 15.6, attending our metabolic clinic after episodes of kidney stones. Essential hypertension was present in 82 patients (35.0%). A difference in the urinary excretion of some of the investigated components was found between subjects with normal blood pressure and those with hypertension. RESULTS: The results showed that hypertensive subjects were older and had a higher body mass index (BMI) and serum uric acid. They had a significantly lower urinary pH (5.6 +/- 0.4 versus 6.0 +/- 0.5) and citrate (2.55 +/- 1.36 versus 2.83 +/- 1.65 mmol/24 h), higher titratable acid (38.8 +/- 19.0 versus 26.8 +/- 15.0 mEq/24 h) and ammonium (41.6 +/- 17.6 versus 34.2 +/-12.4 mmol/24 h). Logistic regression analysis with the presence of hypertension as the dependent variable produced a model with the following predictors: age (P < 0.0001), BMI (P = 0.026), titratable acid (P = 0.025) and low urinary citrate level (P = 0.033). Urinary acid excretion increased with the stage of hypertension. No difference was found in the urinary excretion of other solutes. CONCLUSIONS: These findings suggest that essential hypertension and acid excretion are linked in stone formers. |
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Authors:
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Attilio Losito; Emidio Giovanni Nunzi; Carla Covarelli; Elisabetta Nunzi; Gaetano Ferrara |
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Publication Detail:
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Type: Journal Article Date: 2008-08-20 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 24 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-02-27 Revised Date: 2009-05-21 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Affiliation:
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Struttura Complessa Nefrologia e Dialisi, Università degli studi di Perugia, Perugia, Italy. alosito3@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acids
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urine* Adult Citric Acid / urine Cohort Studies Female Humans Hydrogen-Ion Concentration Hypertension / complications* Kidney Calculi / complications*, urine* Male Middle Aged Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Acids; 77-92-9/Citric Acid |
| Comments/Corrections | |
Comment In:
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Nephrol Dial Transplant. 2009 Jun;24(6):2004; author reply 2004-5
[PMID:
19286692
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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