Document Detail


Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits.
MedLine Citation:
PMID:  14684282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Micelles prepared from polyethyleneglycol/phosphatidyl-ethanolamine conjugates (PEG-PE) with a size of 7-20 nm and zeta-potential of approximately -18 mV were administered i.v. to rabbits with experimental myocardial infarctions. Micelles demonstrated a prolonged circulation in the blood (half-life of 2 h) and accumulated in the infarction zone with efficiency more than 8-fold higher as compared to a non-damaged part of the heart muscle. Obtained results suggest that the enhanced permeability and retention (EPR) effect is the primary mechanism of accumulation of microparticles in the infarct areas, and that drug carriers such as PEG-PE micelles can be used for the delivery of therapeutic or diagnostic agents to an area of myocardial infarction.
Authors:
Anatoly N Lukyanov; William C Hartner; Vladimir P Torchilin
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  94     ISSN:  0168-3659     ISO Abbreviation:  J Control Release     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-19     Completed Date:  2004-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-93     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Avenue, 312 Mugar Building, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Occlusive Diseases / metabolism
Disease Models, Animal
Electrocardiography / drug effects,  methods
Male
Micelles*
Myocardial Infarction / drug therapy,  metabolism*
Phosphatidylethanolamines / administration & dosage,  pharmacokinetics*
Polyethylene Glycols / administration & dosage,  pharmacokinetics*
Rabbits
Grant Support
ID/Acronym/Agency:
R01 EB001961/EB/NIBIB NIH HHS; R01 GM60200/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Micelles; 0/Phosphatidylethanolamines; 0/Polyethylene Glycols; 133906-05-5/dioleoyl-N-(monomethoxypolyethylene glycol succinyl)phosphatidylethanolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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