| Increased umbilical cord plasma interleukin-1 beta levels was correlated with adverse outcomes of neonatal hypoxic-ischemic encephalopathy. | |
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MedLine Citation:
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PMID: 19822562 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To explore whether or not the umbilical blood levels of cytokines can be used to indicate the adverse outcomes of hypoxic-ischemic encephalopathy (HIE) patients. Umbilical artery blood and peripheral venous blood samples were collected on the 1st, 3rd and 7th days after birth to detect the levels of IL-1 beta, IL-8 and TNF-alpha. Neurological examination and Denver developmental screening test (DDST-II) were performed at the 6 and 12 months evaluations to detect any neurodevelopmental abnormalities. The results showed: (i) the serum concentrations of IL-1 beta, IL-8 and TNF-alpha in umbilical and peripheral blood were significantly higher in HIE patients than control groups; (ii) the umbilical blood concentrations of IL-1 beta exhibited the best positive correlation with HIE grades, when compared with IL-8 and TNF-alpha; and (iii) abnormal neurological outcomes at 6 and 12 months of age were best predicted by umbilical levels of IL-1 beta. Thus, umbilical concentrations of IL-1 beta were associated with the grades and adverse outcomes of HIE. |
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Authors:
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Jing Liu; Zhi-Chun Feng |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-12 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 56 ISSN: 1465-3664 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: England |
Other Details:
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Languages: eng Pagination: 178-82 Citation Subset: IM |
Affiliation:
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Department of Neonatology and NICU Feng, Bayi Children's Hospital Affiliated with Beijing Military Region General Hospital, Beijing 100700, China. liujingbj@live.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asphyxia Neonatorum / etiology Case-Control Studies Female Fetal Blood / metabolism* Humans Hypoxia-Ischemia, Brain / blood, cerebrospinal fluid, immunology* Infant, Newborn Interleukin-1beta / blood, cerebrospinal fluid* Interleukin-8 / blood, cerebrospinal fluid* Male Neurologic Examination Pregnancy Reference Values Severity of Illness Index Treatment Outcome Tumor Necrosis Factor-alpha / cerebrospinal fluid* Umbilical Cord / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1beta; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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