Document Detail

Increased transcutaneous oxygen tension in the skin dorsum over the foot in patients with diabetic foot disease in response to the topical use of an emulsion of hyperoxygenated Fatty acids.
MedLine Citation:
PMID:  19825855     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to examine changes in the skin over the feet of patients with diabetic foot syndrome after local application of a product containing hyperoxygenated fatty acids (HOFAs) by measuring transcutaneous oxygen. In 64 patients, transcutaneous oxygen pressure (TcPo(2)) was measured on days 0, 7, 30, 60, and 90 of the study. Foot skin dryness, shedding, and skin color were also assessed using a clinical score. The patients were grouped on the basis of initial levels of transcutaneous oxygen; group 1 comprised patients with TcPo( 2) >30 mm Hg and group 2 comprised patients with TcPo(2) <30 mm Hg on the skin over the dorsum of the feet. Increases in local oxygenation values were observed at a local level in group 2 patients after 30 days of treatment. Skin trophism showed clinical improvement in all patients and these observations may be attributed to improved local microcirculation.
J L L?zaro-Mart?nez; J P S?nchez-R?os; E Garc?a-Morales; A Cecilia-Matilla; T Segovia-G?mez
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-10-13
Journal Detail:
Title:  The international journal of lower extremity wounds     Volume:  8     ISSN:  1552-6941     ISO Abbreviation:  Int J Low Extrem Wounds     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128359     Medline TA:  Int J Low Extrem Wounds     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-93     Citation Subset:  IM    
Universidad Complutense de Madrid, Madrid, Spain.
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MeSH Terms
Administration, Cutaneous
Blood Gas Monitoring, Transcutaneous*
Diabetic Angiopathies / physiopathology
Diabetic Foot / blood,  pathology,  therapy*
Fatty Acids / administration & dosage*
Plant Extracts / administration & dosage*
Skin / blood supply*,  pathology
Reg. No./Substance:
0/Emulsions; 0/Fatty Acids; 0/Mepentol; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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