Document Detail


Increased serum N-terminal pro-B-type natriuretic peptide levels in patients with medial arterial calcification and poorly compressible leg arteries.
MedLine Citation:
PMID:  20947817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether serum levels of N-terminal (NT) pro-B-type natriuretic peptide (pro-BNP) are higher in patients with poorly compressible arteries (PCA) than in patients with peripheral artery disease (PAD) and control subjects without PCA or PAD.
METHODS AND RESULTS: Medial arterial calcification in the lower extremities results in PCA and may be associated with increased arterial stiffness and hemodynamic/myocardial stress. PCA was defined as having an ankle-brachial index >1.4 or an ankle blood pressure >255 mm Hg, whereas PAD was defined as having an ankle-brachial index ≤0.9. Study participants with PCA (n=100; aged 71±10 years; 70% men) and age- and sex-matched patients with PAD (n=300) were recruited from the noninvasive vascular laboratory. Age- and sex-matched controls (n=300) were identified from a community-based cohort and had no history of PAD. NT pro-BNP levels were approximately 2.5-fold higher in patients with PCA than in patients with PAD and approximately 4-fold higher than in age- and sex-matched controls. In multivariable regression analyses that adjusted for age, sex, smoking, hypertension, history of coronary heart disease/stroke, systolic blood pressure, and serum creatinine, NT pro-BNP levels remained significantly higher in patients with PCA than in patients with PAD and controls (P<0.001).
CONCLUSIONS: Patients with medial arterial calcification and PCA have higher serum levels of NT pro-BNP than patients with PAD and controls, which is suggestive of an adverse hemodynamic milieu and increased risk for adverse cardiovascular outcomes.
Authors:
Hayan Jouni; Richard J Rodeheffer; Iftikhar J Kullo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-14
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  31     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-01-20     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Ankle Brachial Index
Arteries / pathology,  physiopathology
Biological Markers / blood
Blood Pressure
Calcinosis / blood*,  diagnosis,  physiopathology
Case-Control Studies
Cross-Sectional Studies
Elasticity
Female
Humans
Linear Models
Lower Extremity / blood supply*
Male
Middle Aged
Minnesota
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Peripheral Arterial Disease / blood*,  diagnosis,  physiopathology
Risk Assessment
Risk Factors
Ultrasonography, Doppler, Duplex
Up-Regulation
Grant Support
ID/Acronym/Agency:
HL-36634/HL/NHLBI NIH HHS; HL-81331/HL/NHLBI NIH HHS; R01 HL036634/HL/NHLBI NIH HHS; R01 HL036634-23/HL/NHLBI NIH HHS; U01 HL081331/HL/NHLBI NIH HHS; U01 HL081331-04/HL/NHLBI NIH HHS; UL1 RR024150/RR/NCRR NIH HHS; UL1 RR024150-06/RR/NCRR NIH HHS; UL1-RR024150/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain
Comments/Corrections

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