Document Detail

Increased Serum Level of Soluble Vascular Endothelial Growth Factor Receptor-1 Is Associated With Poor Coronary Collateralization in Patients With Stable Coronary Artery Disease.
MedLine Citation:
PMID:  24583918     Owner:  NLM     Status:  Publisher    
Background: The present study investigated whether serum levels of soluble vascular endothelial growth factor receptor (sVEGFR)-1, -2 and -3 are related to poor coronary collateralization in patients with stable coronary artery disease (CAD). Methods and Results: Serum levels of sVEGFR-1, -2, -3, VEGF, and placental growth factor (PLGF) were determined in 403 consecutive patients with angiographic total or subtotal occlusion of at least 1 major coronary artery. The degree of collateralization was graded according to the Rentrop scoring system. Low (Rentrop score of 0 or 1) and high (Rentrop score of 2 or 3) coronary collateralization occurred in 161 and 242 patients, respectively. Serum levels of sVEGFR-1 and -2 were significantly elevated, in contrast, VEGF and PLGF levels were remarkably decreased in patients with low collateralization than in those with high collateralization (all P<0.05). Significant differences in sVEGFR-1, VEGF and PLGF levels was consistently detected between the low and high collateralization subgroups for patients with and without type 2 diabetes mellitus (DM) (for all comparisons, P<0.01). Multivariable regression analysis revealed that DM, dyslipidemia, elevated sVEGFR-1, and reduced VEGF and PLGF in serum were independently associated with a low degree of coronary collateralization. Conclusions: Increased serum sVEGFR-1 level is associated with poor coronary collateralization in patients with stable CAD. Type 2 DM is a predominant factor affecting collateral growth in these patients.
Zhen Sun; Ying Shen; Lin Lu; Rui Yan Zhang; Li Jin Pu; Qi Zhang; Zheng Kun Yang; Jian Hu; Qiu Jing Chen; Wei Feng Shen
Related Documents :
24833148 - Mortality indicators and risk factors for intra-abdominal hypertension in severe acute ...
24021678 - Fondaparinux as an alternative to vitamin k antagonists in haemodialysis patients.
19418398 - In vivo diagnosis of acute intestinal graft-versus-host disease by confocal endomicrosc...
16514568 - Frequency of small bowel polyps in patients with duodenal adenoma but without familial ...
7827598 - Colposcopy in women with a normal papanicolaou smear.
24028708 - Association of dialysate calcium concentration with fetuin a level and carotid intima-m...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-28
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-3-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intracellular Calcium and the Mechanism of the Dip in the Anodal Strength-Interval Curve in Cardiac ...
Next Document:  Tobacco Smoking Decreases Plasma Concentration of the Emerging Cardiovascular Risk Marker, L-homoarg...