Document Detail

Increased Risk of Miscarriage and Ectopic Pregnancy among Women with Irritable Bowel Syndrome.
MedLine Citation:
PMID:  22373726     Owner:  NLM     Status:  Publisher    
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is the most commonly diagnosed gastrointestinal condition and is most prevalent in women of reproductive age. We investigated the effects of IBS on risk for adverse outcomes from pregnancy. METHODS: We conducted a cohort study using the UK General Practice Research Database. The study cohort consisted of 100,000 women selected by stratified random sampling from all women with a diagnosis of pregnancy from January 1, 1990 to December 31, 2008. Those with a recorded diagnosis of IBS before pregnancy were identified (n=26,543). Outcome measures were spontaneous miscarriage, ectopic pregnancy, pre-eclampsia and stillbirth. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between IBS and pregnancy outcomes were estimated using logistic regression adjusted for several potential confounders. RESULTS: Of women diagnosed with IBS before pregnancy, 6578 (7%) had a spontaneous miscarriage, 741 (0.74%) had an ectopic pregnancy, 425 (0.43%) developed pre-eclampsia, and 217 (0.22%) had a stillbirth. Maternal IBS was associated with a moderately increased risk of miscarriage (OR=1.21; 95% CI, 1.13-1.30) and ectopic pregnancy (OR=1.28%; 95% CI, 1.06-1.55). There did not appear to be an association between IBS and pre-eclampsia (OR=1.09; 95% CI, 0.85-1.39) or stillbirth (OR=1.00; 95% CI, 0.69-1.44). CONCLUSIONS: IBS, a common disorder in women of reproductive age, appears to increase the risk of miscarriage and ectopic pregnancy. These findings indicate the importance of prenatal care for women with IBS.
Ali S Khashan; Eamonn M M Quigley; Roseanne McNamee; Fergus P McCarthy; Fergus Shanahan; Louise C Kenny
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-25
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  -     ISSN:  1542-7714     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.
Anu Research Centre, Department of Obstetrics and Gynecology, University College Cork, National University of Ireland, Cork, Ireland; Maternal and Fetal Health Research Group, University of Manchester, UK; Anu Research Center, Department of Obstetrics and Gynecology, University College Cork, National University of Ireland, Cork University Maternity Hospital, Ireland.
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