Document Detail

Increased Risk of Coeliac Disease in Patients with Congenital Hypothyroidism.
MedLine Citation:
PMID:  21757873     Owner:  NLM     Status:  Publisher    
Background: In patients with congenital hypothyroidism (CH), the presence of coeliac disease (CD) has been sporadically described. Methods: Seventy-nine consecutive children (58 females and 21 males; age range 3.1-12.1 years) with permanent CH were studied. For all patients, a family history of autoimmune diseases as far as second-degree relatives was collected, and total serum IgA, antigliadin, anti-endomysium and anti-transglutaminase antibodies were evaluated. In the subjects positive for CD antibodies, the CD diagnosis was confirmed by jejunal biopsy. One hundred and eighty-two Italian children from the same geographical area, matched for age and sex, acted as controls. Results: In CH patients, a statistically significant difference was found in the familial occurrence of autoimmune diseases compared to controls (22 vs. 7.9%; p < 0.001). A total of 6 patients (4 girls, 2 boys; 7.6 vs. 1%; p < 0.005) were positive for CD antibodies. In 5 of these patients (6.3%), the diagnosis of CD was confirmed histologically. Conclusion: Our data show a higher prevalence of CD in children with permanent CH and suggest that these patients should be monitored carefully for CD. Other studies are needed to confirm our results and to explain the causes of this possible relationship.
Stefano Stagi; Cristina Manoni; Cecilia Cecchi; Francesco Chiarelli; Maurizio de Martino
Related Documents :
20306353 - Influence of left versus right hemibody onset parkinson's disease on cardiovascular con...
7799003 - Usefulness of movement time in the assessment of parkinson's disease.
20719473 - Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-15
Journal Detail:
Title:  Hormone research in paediatrics     Volume:  -     ISSN:  1663-2826     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525157     Medline TA:  Horm Res Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Department of Paediatrics, University of Florence, Anna Meyer Children's Hospital, Florence, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Subthalamic Local Field Beta Oscillations during Ongoing Deep Brain Stimulation in Parkinson's Disea...
Next Document:  Catamenially Recurring Pneumothorax with Partial Liver Herniation: A Particular View.