Document Detail

Increased risk of benign prostatic enlargement among patients with liver cirrhosis: a nationwide population-based study.
MedLine Citation:
PMID:  20798385     Owner:  NLM     Status:  MEDLINE    
There have been several post mortem studies focusing on the association between liver cirrhosis and benign prostate hyperplasia; however, the results are controversial. The aim of this study was to estimate the risk of benign prostatic enlargement during a 5-year follow-up period following a liver cirrhosis diagnosis, using nationwide population-based data and a retrospective cohort design. We used the "Longitudinal Health Insurance Database," derived from the Taiwan National Health Insurance program. The study cohort comprised 661 patients who had received treatment for liver cirrhosis between 1997 and 2001; the comparison cohort was composed of 3305 randomly selected patients. Stratified Cox proportional hazard regressions were performed as a means of comparing the 5-year benign prostatic enlargement survival rate for the 2 cohorts. Of the sampled patients, 808 patients (20.4%) developed benign prostatic enlargement during the follow-up period (ie, 163 individuals from the study cohort [24.7% of the patients with liver cirrhosis] and 645 individuals from the comparison cohort [19.5% of comparison cohort patients]). The log-rank test indicated that patients with liver cirrhosis had significantly lower 5-year benign prostatic enlargement-free survival rates than the controls (P < .001). The adjusted hazard ratios for benign prostatic enlargement following diagnosis with liver cirrhosis were 1.41 during the 5-year follow-up period. We conclude that the risk for benign prostatic enlargement increased after a diagnosis of liver cirrhosis. Further studies are needed to identify the underlying pathophysiology.
Shiu-Dong Chung; Herng-Ching Lin
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Publication Detail:
Type:  Journal Article     Date:  2010-08-26
Journal Detail:
Title:  Journal of andrology     Volume:  32     ISSN:  1939-4640     ISO Abbreviation:  J. Androl.     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-01-25     Completed Date:  2011-05-19     Revised Date:  2013-01-22    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, and Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
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MeSH Terms
Cohort Studies
Liver Cirrhosis / complications*
Middle Aged
Prostatic Hyperplasia / epidemiology,  etiology*
Risk Factors
Taiwan / epidemiology
Comment In:
J Androl. 2012 Nov-Dec;33(6):1127   [PMID:  22492838 ]
J Urol. 2012 Mar;187(3):971-2   [PMID:  22325527 ]

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