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Increased Risk Of Barrett's Esophagus Among Individuals Born Preterm Or Small For Gestational Age.
MedLine Citation:
PMID:  23376800     Owner:  NLM     Status:  Publisher    
BACKGROUND AND AIMS: Gastro-esophageal reflux is common in infants during their first year in life, and especially in those born preterm or small for gestational age (SGA). We assessed whether being born preterm or SGA increased the risk of developing Barrett's esophagus (BE) in adulthood. METHODS: We performed a population-based case-control study of patients with BE (cases), diagnosed at 2 Swedish hospitals from January 1, 1986 through December 31, 2005. We identified the birth hospital of the cases; data on perinatal characteristics such as gestational age at birth and birth weight were collected from original birth records. We also obtained and collected information on the 3 singleton live births, of the same sex, born after each case at the same maternity ward (controls). In total, we analyzed data from 331 cases and 852 matched controls. We used conditional logistic regression to determine odds ratios (OR), determined 95% confidence intervals (CI), and adjusted for potential confounding factors. RESULTS: Compared with infants born with a normal birth weight (3000-3999 grams), infants with low birth weight (<2500 grams) were at increased risk of BE (adjusted OR, 8.22; 95% CI, 2.83-23.88). This was mainly due to an effect of SGA rather than preterm birth. Specifically, compared with infants with normal birth weight for gestational age (25th to 75th percentile) the odds of BE among very SGA infants (<3rd percentile) was nearly tripled (adjusted OR, 2.95; 95% CI, 1.35-6.44). CONCLUSION: Based on a population-based study of patients with BE in Sweden, infants born SGA have a 3-fold increase in risk for developing BE as adults, compared infants of normal birth weight for gestational age.
Lina Forssell; Sven Cnattingius; Matteo Bottai; Anna-Karin Edstedt Bonamy; Jesper Lagergren; Lars Agréus; Olof Akre
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-31
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  -     ISSN:  1542-7714     ISO Abbreviation:  Clin. Gastroenterol. Hepatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
Department of Neurobiology, Care Sciences and Society, Centre for Family Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden. Electronic address:
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