Document Detail

Increased right ventricular Septomarginal trabeculation mass is a novel marker for pulmonary hypertension: comparison with ventricular mass index and right ventricular mass.
MedLine Citation:
PMID:  21577127     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: : To prospectively evaluate the cardiac magnetic resonance (MR) imaging-derived measurement of right ventricular (RV) septomarginal trabeculation (SMT) mass as a noninvasive marker for pulmonary hypertension (PH), compared with the ventricular mass index (VMI = RV mass/left ventricular mass) and RV mass.
MATERIALS AND METHODS: : A total of 49 patients (60 ± 12 years; 35 female) with suspected PH underwent cardiac MR and right heart catheterization on the same day. Eighteen normal volunteers were also included. The performance of SMT mass, VMI and RV mass measurement, with regard to PH detection, was analyzed using receiver operating characteristic curves. Logistic regression analysis was used to assess the association between SMT mass, RV mass, VMI, and PH.
RESULTS: : The area under the receiver operating characteristic curve for SMT mass/body surface area (BSA), VMI, and RV mass/BSA in diagnosing the presence or absence of PH was 0.88, 0.87, and 0.73 respectively. In multivariable models, both SMT mass/BSA (P = 0.005, odds ratio: 8.6) and VMI (P = 0. 012, odds ratio: 1.1) were found to be significant, independent predictors of PH.
CONCLUSION: : Compared with right heart catheterization measurement, SMT mass and VMI are reproducible and noninvasive MR imaging markers for the diagnosis of PH.
Jens Vogel-Claussen; Monda L Shehata; Dirk Lossnitzer; Jan Skrok; Sukhminder Singh; Danielle Boyce; Noah Lechtzin; Reda E Girgis; Stephen C Mathai; Joao A Lima; David A Bluemke; Paul M Hassoun
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Investigative radiology     Volume:  46     ISSN:  1536-0210     ISO Abbreviation:  Invest Radiol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-09     Completed Date:  2011-12-22     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  567-75     Citation Subset:  IM    
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Aged, 80 and over
Biological Markers*
Cardiac Catheterization
Confidence Intervals
Health Status Indicators
Heart Ventricles / pathology*
Hypertension, Pulmonary / diagnosis*,  pathology
Hypertrophy, Right Ventricular / diagnosis,  pathology*
Logistic Models
Magnetic Resonance Imaging, Cine
Middle Aged
Multivariate Analysis
Odds Ratio
Prospective Studies
ROC Curve
Ventricular Dysfunction, Right / diagnosis*,  pathology
Grant Support
P50 HL084946-01/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Biological Markers

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