Document Detail


Increased Rate of Intracranial Saccular Aneurysms in Acromegaly: An MR Angiography Study and Review of the Literature.
MedLine Citation:
PMID:  21307138     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: The concurrence of intracranial aneurysms and acromegaly has been reported and debated previously. Our study in a large number of patients aimed to verify whether acromegaly patients carry a higher risk of harboring intracranial saccular aneurysms and to evaluate the possible relationship using clinical, laboratory, and imaging techniques. Materials and Methods: A total of 152 of 161 consecutive acromegaly patients (median age, 55.7 yr; 82 females) underwent neuroimaging evaluation of the circle of Willis. Clinical data (disease duration and disease control, hypertension, smoking history, diabetes and dyslipidemia, previous surgery or radiotherapy, previous or current pharmacological therapy), laboratory findings (GH and IGF-I at onset and shortly before examination), and pituitary adenoma imaging features (size and invasiveness of the cavernous sinus) were recorded. Results: Twenty-six patients (17.3%) harbored 40 newly diagnosed intracranial aneurysms; two other patientshadpreviously undergone aneurysm clippingdueto subarachnoid hemorrhage. Ten patients had multiple aneurysms; most of the aneurysms were located in the intracranial tract of the internal carotid artery (67.5%); no aneurysms belonged to the vertebrobasilar circulation. The presence of intracranial aneurysms correlated with GH serum values at disease onset (P < 0.05) and showed a trend to a positive correlation with poor disease control (P = 0.06); no other laboratory, clinical, and radiological findings correlated with the presence of intracranial aneurysms. Conclusions: GH serum excess seems to carry an increased risk of developing intracranial aneurysms. Aneuroradiological evaluation of the intracranial circulation might therefore be considered in the diagnostic work-up of patients affected with acromegaly.
Authors:
Renzo Manara; Pietro Maffei; Valentina Citton; Silvia Rizzati; Giulia Bommarito; Mario Ermani; Irene Albano; Alessandro Della Puppa; Carla Carollo; Giacomo Pavesi; Massimo Scanarini; Filippo Ceccato; Nicola Sicolo; Franco Mantero; Carla Scaroni; Chiara Martini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-9
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neuroradiological Unit (R.M., V.C., G.B., C.C.); Internal Medicine 3, Department of Medical and Surgical Sciences (P.M., I.A., N.S., C.M.); Endocrinology, Department of Medical and Surgical Sciences (S.R., F.C., F.M., C.S.); Department of Neurosciences (M.E.); Neurosurgery, Department of Neurosciences (A.D.P., G.P., M.S.); University Hospital of Padua, 35138 Padua, Italy.
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